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AANAT Produits

(Aralkylamine N-Acetyltransferase (AANAT))
The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009].

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Catégories AANAT en vedette

AANAT Anticorps

High quality antibodies with extensive validation data.

AANAT Kits ELISA

Reliable ELISA kits for a wide range of species.

AANAT Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

AANAT recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human, Mouse, Rat, Sheep
Application ELISA, WB, IF (cc), IF (p), IHC (fro), IHC (p)
Validations
  • (2)
  • (6)
N° du produit ABIN751063
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Rat
Application WB, IHC, ICC, IP
Validations
  • (2)
N° du produit ABIN7444538
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application ELISA, WB, IF
Validations
  • (2)
N° du produit ABIN7169324
Quantité 100 μg
Fiche technique Fiche technique

AANAT recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6965002
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6965001
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6953911
Quantité 96 tests
Fiche technique Fiche technique

AANAT recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1305403
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN7395332
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN7418458
Quantité 100 μg
Fiche technique Fiche technique

Dernières publications sur nos produits AANAT

Xiao, Hu, Song, Zhang, Dong, Jiang, Zhang, Yuan, Zhao: "Profile of melatonin and its receptors and synthesizing enzymes in cumulus-oocyte complexes of the developing sheep antral follicle-a potential estradiol-mediated mechanism." dans: Reproductive biology and endocrinology : RB&E, Vol. 17, Issue 1, pp. 1, (2019) (PubMed).

Ahn, Park, Kim, Lee, Yan, Yong, Lee, CHoi, Yoo, Hwang, Moon, Shin, Won: "Comparison of arylalkylamine N-acetyltransferase and melatonin receptor type 1B immunoreactivity between young adult and aged canine spinal cord." dans: Journal of veterinary science, Vol. 15, Issue 3, pp. 335-42, (2016) (PubMed).

Klein: "Arylalkylamine N-acetyltransferase: "the Timezyme"." dans: The Journal of biological chemistry, Vol. 282, Issue 7, pp. 4233-7, (2007) (PubMed).

Klein, Ganguly, Coon, Shi, Gaildrat, Morin, Weller, Obsil, Hickman, Dyda: "14-3-3 proteins in pineal photoneuroendocrine transduction: how many roles?" dans: Journal of neuroendocrinology, Vol. 15, Issue 4, pp. 370-7, (2003) (PubMed).

Iuvone, Brown, Haque, Weller, Zawilska, Chaurasia, Ma, Klein: "Retinal melatonin production: role of proteasomal proteolysis in circadian and photic control of arylalkylamine N-acetyltransferase." dans: Investigative ophthalmology & visual science, Vol. 43, Issue 2, pp. 564-72, (2002) (PubMed).

Klein, Ganguly, Coon, Weller, Obsil, Hickman, Dyda: "14-3-3 Proteins and photoneuroendocrine transduction: role in controlling the daily rhythm in melatonin." dans: Biochemical Society transactions, Vol. 30, Issue 4, pp. 365-73, (2002) (PubMed).

Coon, Del Olmo, Young, Klein: "Melatonin synthesis enzymes in Macaca mulatta: focus on arylalkylamine N-acetyltransferase (EC 2.3.1.87)." dans: The Journal of clinical endocrinology and metabolism, Vol. 87, Issue 10, pp. 4699-706, (2002) (PubMed).

Coon, Weller, Korf, Namboodiri, Rollag, Klein: "cAmp regulation of arylalkylamine N-acetyltransferase (AANAT, EC 2.3.1.87): a new cell line (1E7) provides evidence of intracellular AANAT activation." dans: The Journal of biological chemistry, Vol. 276, Issue 26, pp. 24097-107, (2001) (PubMed).

Synonymes et noms alternatifs relatifs à AANAT

aralkylamine N-acetyltransferase (AANAT), aralkylamine N-acetyltransferase (Aanat), arylalkylamine N-acetyltransferase (Aanat), AA-NAT, DSPS, Nat-2, Nat4, SNAT, Snat

Protein level used designations for AANAT

  • arylalkylamine N-acetyltransferase
  • serotonin N-acetyltransferase
  • serotonin acetylase
  • Arylalkylamine N - acetyltransferase (Serotonin N - acetyltransferase)
  • Seretonin N-acetyltransferase
  • arylakylamine N-acetyltransferase
  • AA-NAT
  • pineal serotonin N-acetyltransferase
  • pineal arylalkylamine N-acetyltransferase
  • aralkylamine N-acetyltransferase
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