ABL1 Produits
(C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1))
Catégories
The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9\;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. [provided by RefSeq, Jul 2008].
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Catégories ABL1 en vedette
ABL1 Anticorps
High quality antibodies with extensive validation data.
ABL1 Kits ELISA
Reliable ELISA kits for a wide range of species.
ABL1 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
ABL1 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IHC, IF
Validations
- (6)
N° du produit
ABIN3020872
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IF, IHC (p), DB
Validations
- (1)
- (4)
N° du produit
ABIN6241067
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human, Monkey, Mouse, Rat
Application
WB, ELISA, IF, ICC
Validations
- (1)
- (4)
N° du produit
ABIN6256686
Quantité
100 μL
Fiche technique
Fiche technique
ABL1 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
- (3)
N° du produit
ABIN6730567
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6975039
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
N° du produit
ABIN1380761
Quantité
2 x 96 tests
Fiche technique
Fiche technique
ABL1 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN2565131
Quantité
25 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Baculovirus infected Insect Cells
Validations
- (1)
N° du produit
ABIN7317077
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (2)
- (1)
N° du produit
ABIN1047855
Quantité
100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits ABL1
: "Defining the target and the effect of imatinib on the filarial c-Abl homologue." dans: PLoS neglected tropical diseases, Vol. 11, Issue 7, pp. e0005690, (2017) (PubMed).: "A sensitive and microscale method for drug screening combining affinity probes and single molecule fluorescence correlation spectroscopy." dans: The Analyst, Vol. 140, Issue 4, pp. 1207-14, (2015) (PubMed).
: "Autophagy as an essential cellular antioxidant pathway in neurodegenerative disease." dans: Redox biology, Vol. 2, pp. 82-90, (2015) (PubMed).
: "Altered expression of c-Abl in patients with epilepsy and in a rat model." dans: Synapse (New York, N.Y.), Vol. 68, Issue 7, pp. 306-16, (2014) (PubMed).
: "MEK-dependent negative feedback underlies BCR-ABL-mediated oncogene addiction." dans: Cancer discovery, Vol. 4, Issue 2, pp. 200-15, (2014) (PubMed).
: "Reduced miR-3127-5p expression promotes NSCLC proliferation/invasion and contributes to dasatinib sensitivity via the c-Abl/Ras/ERK pathway." dans: Scientific reports, Vol. 4, pp. 6527, (2014) (PubMed).
: "Non-receptor-tyrosine kinases integrate fast glucocorticoid signaling in hippocampal neurons." dans: The Journal of biological chemistry, Vol. 288, Issue 33, pp. 23725-39, (2013) (PubMed).
: "Fragment-hopping-based discovery of a novel chemical series of proto-oncogene PIM-1 kinase inhibitors." dans: PLoS ONE, Vol. 7, Issue 10, pp. e45964, (2012) (PubMed).
: "Presenilin is necessary for efficient proteolysis through the autophagy-lysosome system in a ?-secretase-independent manner." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 31, Issue 8, pp. 2781-91, (2011) (PubMed).
: "Tyrosine 311 is phosphorylated by c-Abl and promotes the apoptotic effect of PKCdelta in glioma cells." dans: Biochemical and biophysical research communications, Vol. 352, Issue 2, pp. 431-6, (2006) (PubMed).
Synonymes et noms alternatifs relatifs à ABL1
ABL proto-oncogene 1, non-receptor tyrosine kinase (ABL1), c-abl oncogene 1, non-receptor tyrosine kinase (Abl1), ABL proto-oncogene 1, non-receptor tyrosine kinase (Abl1), Tyrosine-protein kinase abl-1 (abl-1), c-abl oncogene 1, non-receptor tyrosine kinase (abl1), ABL, Abl, AI325092, bcr/abl, c-ABL, c-Abl, E430008G22Rik, JTK7, p150, v-ablProtein level used designations for ABL1
- Abelson tyrosine-protein kinase 1
- bcr/c-abl oncogene protein
- c-abl oncogene 1, receptor tyrosine kinase
- proto-oncogene c-Abl
- proto-oncogene tyrosine-protein kinase ABL1
- tyrosine-protein kinase ABL1
- v-abl Abelson murine leukemia viral oncogene homolog 1
- Abelson murine leukemia oncogene
- abelson murine leukemia viral oncogene homolog 1
- p150
- v-abl Abelson murine leukemia oncogene 1
- Abelson murine leukemia viral (v-abl) oncogene homolog 1
- v-abl Abelson murine leukemia viral oncogene 1
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