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ABL1 Produits

(C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1))
The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9\;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. [provided by RefSeq, Jul 2008].

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Catégories ABL1 en vedette

ABL1 Anticorps

High quality antibodies with extensive validation data.

ABL1 Kits ELISA

Reliable ELISA kits for a wide range of species.

ABL1 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

ABL1 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, IHC, IF
Validations
  • (6)
N° du produit ABIN3020872
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, IF, IHC (p), DB
Validations
  • (1)
  • (4)
N° du produit ABIN6241067
Quantité 400 μL
Fiche technique Fiche technique
Reactivity Human, Monkey, Mouse, Rat
Application WB, ELISA, IF, ICC
Validations
  • (1)
  • (4)
N° du produit ABIN6256686
Quantité 100 μL
Fiche technique Fiche technique

ABL1 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Semi-Quantitative Sandwich ELISA
Validations
  • (3)
N° du produit ABIN6730567
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6975039
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human, Mouse, Rat
Analytical Method Qualitative Cell ELISA
Validations
N° du produit ABIN1380761
Quantité 2 x 96 tests
Fiche technique Fiche technique

ABL1 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN2565131
Quantité 25 μg
Fiche technique Fiche technique
Reactivity Human
Source Baculovirus infected Insect Cells
Validations
  • (1)
N° du produit ABIN7317077
Quantité 50 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (2)
  • (1)
N° du produit ABIN1047855
Quantité 100 μg
Fiche technique Fiche technique

Dernières publications sur nos produits ABL1

OConnell, Kamenyeva, Lustigman, Bell, Nutman: "Defining the target and the effect of imatinib on the filarial c-Abl homologue." dans: PLoS neglected tropical diseases, Vol. 11, Issue 7, pp. e0005690, (2017) (PubMed).

Ruan, Su, Shao, Wang, Dong, Huang, Ren: "A sensitive and microscale method for drug screening combining affinity probes and single molecule fluorescence correlation spectroscopy." dans: The Analyst, Vol. 140, Issue 4, pp. 1207-14, (2015) (PubMed).

Giordano, Darley-Usmar, Zhang: "Autophagy as an essential cellular antioxidant pathway in neurodegenerative disease." dans: Redox biology, Vol. 2, pp. 82-90, (2015) (PubMed).

Chen, Wang, Tang, Fang, Li, Chen, Wang: "Altered expression of c-Abl in patients with epilepsy and in a rat model." dans: Synapse (New York, N.Y.), Vol. 68, Issue 7, pp. 306-16, (2014) (PubMed).

Asmussen, Lasater, Tajon, Oses-Prieto, Jun, Taylor, Burlingame, Craik, Shah: "MEK-dependent negative feedback underlies BCR-ABL-mediated oncogene addiction." dans: Cancer discovery, Vol. 4, Issue 2, pp. 200-15, (2014) (PubMed).

Sun, Chen, Zhang, Xie, Hou, Hui, Xu, Du, Zhou, Su, Gao: "Reduced miR-3127-5p expression promotes NSCLC proliferation/invasion and contributes to dasatinib sensitivity via the c-Abl/Ras/ERK pathway." dans: Scientific reports, Vol. 4, pp. 6527, (2014) (PubMed).

Yang, Roselli, Patchev, Yu, Almeida: "Non-receptor-tyrosine kinases integrate fast glucocorticoid signaling in hippocampal neurons." dans: The Journal of biological chemistry, Vol. 288, Issue 33, pp. 23725-39, (2013) (PubMed).

Saluste, Albarran, Alvarez, Rabal, Ortega, Blanco, Kurz, Salgado, Pevarello, Bischoff, Pastor, Oyarzabal: "Fragment-hopping-based discovery of a novel chemical series of proto-oncogene PIM-1 kinase inhibitors." dans: PLoS ONE, Vol. 7, Issue 10, pp. e45964, (2012) (PubMed).

Neely, Green, LaFerla: "Presenilin is necessary for efficient proteolysis through the autophagy-lysosome system in a ?-secretase-independent manner." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 31, Issue 8, pp. 2781-91, (2011) (PubMed).

Lu, Finnis, Xiang, Lee, Markowitz, Okhrimenko, Brodie: "Tyrosine 311 is phosphorylated by c-Abl and promotes the apoptotic effect of PKCdelta in glioma cells." dans: Biochemical and biophysical research communications, Vol. 352, Issue 2, pp. 431-6, (2006) (PubMed).

Synonymes et noms alternatifs relatifs à ABL1

ABL proto-oncogene 1, non-receptor tyrosine kinase (ABL1), c-abl oncogene 1, non-receptor tyrosine kinase (Abl1), ABL proto-oncogene 1, non-receptor tyrosine kinase (Abl1), Tyrosine-protein kinase abl-1 (abl-1), c-abl oncogene 1, non-receptor tyrosine kinase (abl1), ABL, Abl, AI325092, bcr/abl, c-ABL, c-Abl, E430008G22Rik, JTK7, p150, v-abl

Protein level used designations for ABL1

  • Abelson tyrosine-protein kinase 1
  • bcr/c-abl oncogene protein
  • c-abl oncogene 1, receptor tyrosine kinase
  • proto-oncogene c-Abl
  • proto-oncogene tyrosine-protein kinase ABL1
  • tyrosine-protein kinase ABL1
  • v-abl Abelson murine leukemia viral oncogene homolog 1
  • Abelson murine leukemia oncogene
  • abelson murine leukemia viral oncogene homolog 1
  • p150
  • v-abl Abelson murine leukemia oncogene 1
  • Abelson murine leukemia viral (v-abl) oncogene homolog 1
  • v-abl Abelson murine leukemia viral oncogene 1
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