ACPP Produits
(Acid Phosphatase, Prostate (ACPP))
Catégories
This gene encodes a multidomain protein containing an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology (PH) domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal Src homology 3 (SH3) domain. The protein localizes in the Golgi apparatus and at the plasma membrane, where it colocalizes with protein tyrosine kinase 2-beta (PYK2). The encoded protein forms a stable complex with PYK2 in vivo. This interaction appears to be mediated by binding of its SH3 domain to the C-terminal proline-rich domain of PYK2. The encoded protein is tyrosine phosphorylated by activated PYK2. It has catalytic activity for class I and II ArfGAPs in vitro, and can bind the class III Arf ARF6 without immediate GAP activity. The encoded protein is believed to function as an ARF GAP that controls ARF-mediated vesicle budding when recruited to Golgi membranes. In addition, it functions as a substrate and downstream target for PYK2 and SRC, a pathway that may be involved in the regulation of vesicular transport. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008].
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Catégories ACPP en vedette
ACPP Anticorps
High quality antibodies with extensive validation data.
ACPP Kits ELISA
Reliable ELISA kits for a wide range of species.
ACPP Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
ACPP recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (9)
N° du produit
ABIN7431248
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (7)
N° du produit
ABIN7438529
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC, IF
Validations
- (6)
N° du produit
ABIN3022672
Quantité
100 μL
Fiche technique
Fiche technique
ACPP recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6964540
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6953397
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Pig
Analytical Method
Quantitative
Validations
N° du produit
ABIN777999
Quantité
96 tests
Fiche technique
Fiche technique
ACPP recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Human
Validations
- (1)
N° du produit
ABIN934762
Quantité
1 mg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1305693
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1305691
Quantité
10 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits ACPP
: "Pharmacological targeting of plasmin prevents lethality in a murine model of macrophage activation syndrome." dans: Blood, Vol. 130, Issue 1, pp. 59-72, (2017) (PubMed).: "Prostatic Acid Phosphatase Alters the RANKL/OPG System and Induces Osteoblastic Prostate Cancer Bone Metastases." dans: Endocrinology, Vol. 157, Issue 12, pp. 4526-4533, (2016) (PubMed).
: "Mice deficient in transmembrane prostatic acid phosphatase display increased GABAergic transmission and neurological alterations." dans: PLoS ONE, Vol. 9, Issue 5, pp. e97851, (2014) (PubMed).
: "Evaluation of protein biomarkers of prostate cancer aggressiveness." dans: BMC cancer, Vol. 14, pp. 244, (2014) (PubMed).
: "An evolutionarily conserved mode of modulation of Shaw-like K? channels." dans: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 27, Issue 4, pp. 1381-93, (2013) (PubMed).
: "Variance decomposition of protein profiles from antibody arrays using a longitudinal twin model." dans: Proteome science, Vol. 9, pp. 73, (2011) (PubMed).
: "Consolidation therapy with low-dose thalidomide and prednisolone prolongs the survival of multiple myeloma patients undergoing a single autologous stem-cell transplantation procedure." dans: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Vol. 27, Issue 11, pp. 1788-93, (2009) (PubMed).
: "Clinical collection and protein properties of expressed prostatic secretions as a source for biomarkers of prostatic disease." dans: Journal of proteomics, Vol. 72, Issue 6, pp. 907-17, (2009) (PubMed).
: "Identification of HLA-DRB1*1501-restricted T-cell epitopes from human prostatic acid phosphatase." dans: The Prostate, Vol. 67, Issue 10, pp. 1019-28, (2007) (PubMed).
: "Prostatic acid phosphatase is not a prostate specific target." dans: Cancer research, Vol. 67, Issue 14, pp. 6549-54, (2007) (PubMed).
Synonymes et noms alternatifs relatifs à ACPP
acid phosphatase, prostate (ACPP), ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 (ASAP2), acid phosphatase, prostate (Acpp), prostatic acid phosphatase (CpipJ_CPIJ004002), prostatic acid phosphatase, putative (Smp_016640), acid phosphatase, prostate S homeolog (acpp.S), 5'-NT, A030005E02Rik, ACP-3, acp-3, ACP3, acp3, ACPP, Acpp11, acpt, AMAP2, CENTB3, DDEF2, FRAP, Lap, PAG3, PAP, pap, Pap-alpha, Ppal, RNACPP11, SHAG1Protein level used designations for ACPP
- 5'-nucleotidase
- TMPase
- ecto-5'-nucleotidase
- prostatic acid phosphatase
- prostatic acid phosphotase
- thiamine monophosphatase
- PYK2 C terminus-associated protein
- arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2
- centaurin, beta 3
- development and differentiation enhancing factor 2
- development and differentiation-enhancing factor 2
- paxillin-associated protein with ARF GAP activity 3
- pyk2 C-terminus-associated protein
- fluoride-resistant acid phosphatase
- lysosomal acid phosphatase
- prostatic acid phosphatase (rPAP)
- acid phosphatase, prostate
- tyrosine acid phosphatase
- prostatic acid phosphatase-like
- testicular acid phosphatase homolog
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