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ACVR1 Produits

(Activin Receptor Type I (ACRV1))
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling\; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq, Jul 2008].

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Catégories ACVR1 en vedette

ACVR1 Anticorps

High quality antibodies with extensive validation data.

ACVR1 Kits ELISA

Reliable ELISA kits for a wide range of species.

ACVR1 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

ACVR1 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, IHC (p)
Validations
  • (2)
  • (4)
N° du produit ABIN392240
Quantité 400 μL
Fiche technique Fiche technique
Reactivity Human, Mouse
Application WB
Validations
  • (1)
  • (3)
N° du produit ABIN391156
Quantité 400 μL
Fiche technique Fiche technique
Reactivity Human, Mouse
Application WB, IHC (p)
Validations
  • (4)
N° du produit ABIN657718
Quantité 400 μL
Fiche technique Fiche technique

ACVR1 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6953435
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Competition ELISA
Validations
N° du produit ABIN1742678
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Sheep
Analytical Method
Validations
N° du produit ABIN1773582
Quantité 96 tests
Fiche technique Fiche technique

ACVR1 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1305799
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1305801
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Mouse
Source HEK-293 Cells
Validations
  • (1)
N° du produit ABIN7194135
Quantité 200 μg
Fiche technique Fiche technique

Dernières publications sur nos produits ACVR1

Tengroth, Arebro, Larsson, Bachert, Georén, Cardell: "Activation of Activin receptor-like kinases curbs mucosal inflammation and proliferation in chronic rhinosinusitis with nasal polyps." dans: Scientific reports, Vol. 8, Issue 1, pp. 1561, (2018) (PubMed).

Toofan, Busch, Morrison, OBrien, Jørgensen, Copland, Wheadon: "Chronic myeloid leukaemia cells require the bone morphogenic protein pathway for cell cycle progression and self-renewal." dans: Cell death & disease, Vol. 9, Issue 9, pp. 927, (2018) (PubMed).

Fujimoto, Ohte, Shin, Yoneyama, Osawa, Miyamoto, Tsukamoto, Mizuta, Kokabu, Machiya, Okuda, Suda, Katagiri: "Establishment of a novel model of chondrogenesis using murine embryonic stem cells carrying fibrodysplasia ossificans progressiva-associated mutant ALK2." dans: Biochemical and biophysical research communications, Vol. 455, Issue 3-4, pp. 347-52, (2014) (PubMed).

Kan, Liu, McGuire, Berger, Awatramani, Dymecki, Kessler: "Dysregulation of local stem/progenitor cells as a common cellular mechanism for heterotopic ossification." dans: Stem cells (Dayton, Ohio), Vol. 27, Issue 1, pp. 150-6, (2009) (PubMed).

Mitu, Wang, Hirschberg: "BMP7 is a podocyte survival factor and rescues podocytes from diabetic injury." dans: American journal of physiology. Renal physiology, Vol. 293, Issue 5, pp. F1641-8, (2007) (PubMed).

Shore, Xu, Feldman, Fenstermacher, Cho, Choi, Connor, Delai, Glaser, LeMerrer, Morhart, Rogers, Smith, Triffitt, Urtizberea, Zasloff, Brown, Kaplan: "A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva." dans: Nature genetics, Vol. 38, Issue 5, pp. 525-7, (2006) (PubMed).

Weber, Teresi, Broelsch, Frilling, Eng: "A limited set of human MicroRNA is deregulated in follicular thyroid carcinoma." dans: The Journal of clinical endocrinology and metabolism, Vol. 91, Issue 9, pp. 3584-91, (2006) (PubMed).

Masood, Kumar, Sinha, Crowe, Krasnoperov, Reddy, Zozulya, Singh, Xia, Broek, Schönthal, Gill: "EphB4 provides survival advantage to squamous cell carcinoma of the head and neck." dans: International journal of cancer, Vol. 119, Issue 6, pp. 1236-48, (2006) (PubMed).

Casagrandi, Bearfield, Geary, Redman, Muttukrishna: "Inhibin, activin, follistatin, activin receptors and beta-glycan gene expression in the placental tissue of patients with pre-eclampsia." dans: Molecular human reproduction, Vol. 9, Issue 4, pp. 199-203, (2003) (PubMed).

Schneider-Kolsky, Manuelpillai, Waldron, Dole, Wallace: "The distribution of activin and activin receptors in gestational tissues across human pregnancy and during labour." dans: Placenta, Vol. 23, Issue 4, pp. 294-302, (2002) (PubMed).

Synonymes et noms alternatifs relatifs à ACVR1

activin A receptor type 1 (ACVR1), activin A receptor type 1 (Acvr1), activin A receptor, type 1 (Acvr1), activin A receptor type 1 S homeolog (acvr1.S), ActR-I, ActR-IA, ACTRI, actri, ActRIA, Acvr, acvr1, acvr1-a, acvr1-b, ACVR1A, acvr1a, ACVRLK2, Acvrlk2, acvrlk2, Alk-2, alk-2, ALK2, alk2, Alk8, alk8, D330013D15Rik, FOP, fop, sax, SKR1, skr1, Tsk7L, TSRI, tsri, xALK-2

Protein level used designations for ACVR1

  • TGF-B superfamily receptor type I
  • activin A receptor, type II-like kinase 2
  • activin receptor type I
  • activin receptor type-1
  • activin receptor-like kinase 2
  • hydroxyalkyl-protein kinase
  • serine/threonine-protein kinase receptor R1
  • ACTR-I
  • SKR1
  • TSR-I
  • activin A receptor, type 1
  • activin type I receptor
  • type I TGF B receptor
  • activin A receptor, type I
  • activin receptor type IA
  • TSK-7L
  • activin A receptor type 1 S homeolog
  • activin A receptor type I S homeolog
  • activin receptor like kinase-2
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