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ACVR2B Produits

(Activin A Receptor, Type IIB (ACVR2B))

Catégories

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling\; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq, Jul 2008].

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Catégories ACVR2B en vedette

ACVR2B Anticorps

High quality antibodies with extensive validation data.

ACVR2B Kits ELISA

Reliable ELISA kits for a wide range of species.

ACVR2B Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

ACVR2B recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rat, Sheep, Zebrafish (Danio rerio)
Application WB
Validations
  • (5)
N° du produit ABIN2782110
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human, Rat
Application WB, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro)
Validations
  • (3)
N° du produit ABIN1714650
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB
Validations
  • (1)
  • (2)
N° du produit ABIN391162
Quantité 400 μL
Fiche technique Fiche technique

ACVR2B recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6953430
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
N° du produit ABIN4881730
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Semi-Quantitative Sandwich ELISA
Validations
N° du produit ABIN6385086
Quantité 96 tests
Fiche technique Fiche technique

ACVR2B recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1305815
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1305817
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Mouse
Source HEK-293 Cells
Validations
  • (1)
N° du produit ABIN7320385
Quantité 100 μg
Fiche technique Fiche technique

Dernières publications sur nos produits ACVR2B

Iwata, Hacia, Suzuki, Sanchez-Lara, Urata, Chai: "Modulation of noncanonical TGF-? signaling prevents cleft palate in Tgfbr2 mutant mice." dans: The Journal of clinical investigation, Vol. 122, Issue 3, pp. 873-85, (2012) (PubMed).

McKay, Ogborn, Bellamy, Tarnopolsky, Parise: "Myostatin is associated with age-related human muscle stem cell dysfunction." dans: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 26, Issue 6, pp. 2509-21, (2012) (PubMed).

Martins da Silva, Bayne, Cambray, Hartley, McNeilly, Anderson: "Expression of activin subunits and receptors in the developing human ovary: activin A promotes germ cell survival and proliferation before primordial follicle formation." dans: Developmental biology, Vol. 266, Issue 2, pp. 334-45, (2004) (PubMed).

Harrison, Gray, Fischer, Donaldson, Choe, Vale: "An activin mutant with disrupted ALK4 binding blocks signaling via type II receptors." dans: The Journal of biological chemistry, Vol. 279, Issue 27, pp. 28036-44, (2004) (PubMed).

Casagrandi, Bearfield, Geary, Redman, Muttukrishna: "Inhibin, activin, follistatin, activin receptors and beta-glycan gene expression in the placental tissue of patients with pre-eclampsia." dans: Molecular human reproduction, Vol. 9, Issue 4, pp. 199-203, (2003) (PubMed).

Synonymes et noms alternatifs relatifs à ACVR2B

activin A receptor type 2B (ACVR2B), activin A receptor type 2B (acvr2b), activin A receptor type 2B L homeolog (acvr2b.L), activin A receptor type 2B (Acvr2b), activin A receptor type 2Ba (acvr2ba), activin receptor IIB (Acvr2b), actr-iib, ActR-IIB, actr2b, actriib, ACTRIIB, ActRIIB, actrIIb, ACVR2B, HTX4, wu:fj97d11, XAR1

Protein level used designations for ACVR2B

  • activin A receptor, type IIB
  • activin receptor type IIB
  • activin receptor type-2B-like
  • activin type IIB receptor
  • activin receptor type-2B
  • ACTR-IIB
  • testicular activin receptor IIB
  • ActRIIB type II activin receptor B
  • Activine receptor 2b (transmembrane serine kinase)
  • activin receptor IIB
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