AKR1C3 Produits
(Aldo-Keto Reductase Family 1, Member C3 (3-alpha Hydroxysteroid Dehydrogenase, Type II) (AKR1C3))
Catégories
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011].
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Catégories AKR1C3 en vedette
AKR1C3 Anticorps
High quality antibodies with extensive validation data.
AKR1C3 Kits ELISA
Reliable ELISA kits for a wide range of species.
AKR1C3 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
AKR1C3 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IF, IHC (p), IP, ICC
Validations
- (5)
N° du produit
ABIN2855872
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, IF, ICC
Validations
- (5)
N° du produit
ABIN6259862
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IF, IP
Validations
- (5)
N° du produit
ABIN3022536
Quantité
100 μL
Fiche technique
Fiche technique
AKR1C3 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN4881786
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN5594185
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
N° du produit
ABIN6385765
Quantité
96 tests
Fiche technique
Fiche technique
AKR1C3 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN666747
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1344760
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Human Cells
Validations
N° du produit
ABIN4370834
Quantité
50 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits AKR1C3
: "Production of prostaglandins in placentae and corpus luteum in pregnant hinds of red deer (Cervus elaphus)." dans: Theriogenology, Vol. 85, Issue 4, pp. 762-8, (2016) (PubMed).: "Interindividual variability in the cardiac expression of anthracycline reductases in donors with and without Down syndrome." dans: Pharmaceutical research, Vol. 31, Issue 7, pp. 1644-55, (2014) (PubMed).
: "Induction of PGF2? synthesis by cortisol through GR dependent induction of CBR1 in human amnion fibroblasts." dans: Endocrinology, Vol. 155, Issue 8, pp. 3017-24, (2014) (PubMed).
: "Elevated expression of AKR1C3 increases resistance of cancer cells to ionizing radiation via modulation of oxidative stress." dans: PLoS ONE, Vol. 9, Issue 11, pp. e111911, (2014) (PubMed).
: "Testosterone synthesis in patients with 17β-hydroxysteroid dehydrogenase 3 deficiency." dans: Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation, Vol. 6, Issue 4, pp. 161-8, (2012) (PubMed).
: "Proteasome inhibitors MG-132 and bortezomib induce AKR1C1, AKR1C3, AKR1B1, and AKR1B10 in human colon cancer cell lines SW-480 and HT-29." dans: Chemico-biological interactions, Vol. 191, Issue 1-3, pp. 239-49, (2011) (PubMed).
: "The dual 5-alpha-reductase inhibitor dutasteride induces atrophic changes and decreases relative cancer volume in human prostate." dans: Urology, Vol. 65, Issue 1, pp. 76-82, (2005) (PubMed).
Synonymes et noms alternatifs relatifs à AKR1C3
aldo-keto reductase family 1, member C3 L homeolog (akr1c3.L), aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) (AKR1C3), aldo-keto reductase family 1 member C2 (LOC722496), aldo-keto reductase family 1 member C3 (AKR1C3), aldo-keto reductase family 1, member C3 (Akr1c3), AKR1C3, Akr1c18, DD3, DDX, HA1753, HAKRB, HAKRe, hluPGFS, HSD17B5, MGC134333, PGFSProtein level used designations for AKR1C3
- aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
- prostaglandin F synthase
- aldo-keto reductase family 1 member C3 homolog
- 3-alpha hydroxysteroid dehydrogenase, type II
- 3-alpha-HSD type II, brain
- aldo-keto reductase family 1 member C3
- chlordecone reductase homolog HAKRb
- dihydrodiol dehydrogenase 3
- dihydrodiol dehydrogenase X
- indanol dehydrogenase
- testosterone 17-beta-dehydrogenase 5
- trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
- type IIb 3-alpha hydroxysteroid dehydrogenase
- 20 alpha-hydroxysteroid dehydrogenase
- 20-alpha-HSD
- 20-alpha-hydroxysteroid dehydrogenase
- 20alpha-hydroxysteroid dehydrogenase
- HSD1
- aldo-keto reductase family 1 member C18
- aldo-keto reductase family 1, member C18
- 17-beta-HSD 5
- 17-beta-hydroxysteroid dehydrogenase type 5
- 3-alpha-HSD type 2
- 3-alpha-hydroxysteroid dehydrogenase type 2
- PGFS
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