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ALOX5AP Produits

(Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP))
This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2011].

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Catégories ALOX5AP en vedette

ALOX5AP Anticorps

High quality antibodies with extensive validation data.

ALOX5AP Kits ELISA

Reliable ELISA kits for a wide range of species.

ALOX5AP Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

ALOX5AP recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application ELISA, IHC, FACS, IF
Validations
  • (7)
N° du produit ABIN185249
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA, IHC
Validations
  • (3)
N° du produit ABIN185717
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application WB, IHC (p)
Validations
  • (2)
N° du produit ABIN392385
Quantité 400 μL
Fiche technique Fiche technique

ALOX5AP recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6964996
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
N° du produit ABIN6730404
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Mouse
Analytical Method
Validations
N° du produit ABIN1122348
Quantité 96 tests
Fiche technique Fiche technique

ALOX5AP recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1344923
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
N° du produit ABIN3096858
Quantité 1 mg
Fiche technique Fiche technique
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
N° du produit ABIN3133653
Quantité 1 mg
Fiche technique Fiche technique

Dernières publications sur nos produits ALOX5AP

Schmider, Vaught, Bauer, Elliott, Godin, Ellis, Nigrovic, Soberman: "The organization of leukotriene biosynthesis on the nuclear envelope revealed by single molecule localization microscopy and computational analyses." dans: PLoS ONE, Vol. 14, Issue 2, pp. e0211943, (2019) (PubMed).

Huang, Sharifpanah, Becker, Wartenberg, Sauer: "Impact of Arachidonic Acid and the Leukotriene Signaling Pathway on Vasculogenesis of Mouse Embryonic Stem Cells." dans: Cells, tissues, organs, Vol. 201, Issue 5, pp. 319-32, (2016) (PubMed).

Elias, Ferré, Vilà, Muñoz, Casellas, Garcia, Molas, Agudo, Roca, Ruberte, Bosch, Franckhauser: "ALOX5AP Overexpression in Adipose Tissue Leads to LXA4 Production and Protection Against Diet-Induced Obesity and Insulin Resistance." dans: Diabetes, Vol. 65, Issue 8, pp. 2139-50, (2016) (PubMed).

van der Laan, Foroughi Asl, van den Borne, van Setten, van der Perk, van de Weg, Schoneveld, de Kleijn, Michoel, Björkegren, den Ruijter, Asselbergs, de Bakker, Pasterkamp: "Variants in ALOX5, ALOX5AP and LTA4H are not associated with atherosclerotic plaque phenotypes: the Athero-Express Genomics Study." dans: Atherosclerosis, Vol. 239, Issue 2, pp. 528-38, (2015) (PubMed).

Zhang, Yu, Ni, Shen, Das: "Growth inhibitory effect of polyunsaturated fatty acids (PUFAs) on colon cancer cells via their growth inhibitory metabolites and fatty acid composition changes." dans: PLoS ONE, Vol. 10, Issue 4, pp. e0123256, (2015) (PubMed).

Perisic, Hedin, Razuvaev, Lengquist, Osterholm, Folkersen, Gillgren, Paulsson-Berne, Ponten, Odeberg, Hedin: "Profiling of atherosclerotic lesions by gene and tissue microarrays reveals PCSK6 as a novel protease in unstable carotid atherosclerosis." dans: Arteriosclerosis, thrombosis, and vascular biology, Vol. 33, Issue 10, pp. 2432-43, (2013) (PubMed).

Finkensieper, Kieser, Bekhite, Richter, Mueller, Graebner, Figulla, Sauer, Wartenberg: "The 5-lipoxygenase pathway regulates vasculogenesis in differentiating mouse embryonic stem cells." dans: Cardiovascular research, Vol. 86, Issue 1, pp. 37-44, (2010) (PubMed).

Maier, Tausch, Hoernig, Coste, Schmidt, Angioni, Metzner, Groesch, Pergola, Steinhilber, Werz, Geisslinger: "Celecoxib inhibits 5-lipoxygenase." dans: Biochemical pharmacology, Vol. 76, Issue 7, pp. 862-72, (2008) (PubMed).

Kaaman, Rydén, Axelsson, Nordström, Sicard, Bouloumié, Langin, Arner, Dahlman: "ALOX5AP expression, but not gene haplotypes, is associated with obesity and insulin resistance." dans: International journal of obesity (2005), Vol. 30, Issue 3, pp. 447-52, (2006) (PubMed).

Helgadottir, Manolescu, Thorleifsson, Gretarsdottir, Jonsdottir, Thorsteinsdottir, Samani, Gudmundsson, Grant, Thorgeirsson, Sveinbjornsdottir, Valdimarsson, Matthiasson, Johannsson, Gudmundsdottir et al.: "The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. ..." dans: Nature genetics, Vol. 36, Issue 3, pp. 233-9, (2004) (PubMed).

Synonymes et noms alternatifs relatifs à ALOX5AP

arachidonate 5-lipoxygenase-activating protein (alox5ap), arachidonate 5-lipoxygenase activating protein (ALOX5AP), arachidonate 5-lipoxygenase activating protein (alox5ap), arachidonate 5-lipoxygenase activating protein (Alox5ap), al5ap, Alox5ap, ALOX5AP, fj65d02, flap, Flap, FLAP, wu:fj65d02, zgc:63982

Protein level used designations for ALOX5AP

  • arachidonate 5-lipoxygenase-activating protein
  • Arachidonate 5-lipoxygenase-activating protein
  • MK-886-binding protein
  • arachidonate 5 lipoxygenase activating protein
  • 5-lipoxygenase-activating protein FLAP
  • FLAP
  • arachidonate 5-lipoxygenase activating protein
  • 5-lipoxygenase-activating protein
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