ANGL4 Protein (AA 28-403, partial) (GST tag)
ANGL4
Origine: Humain
Hôte: Escherichia coli (E. coli)
Recombinant
> 90 %
SDS
1 image
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- Antigène
- ANGL4 (Angiopoietin-Related Protein 4 (ANGL4))
- Type de proteíne
- Recombinant
- Attributs du protein
- AA 28-403, partial
- Origine
- Humain
- Source
- Escherichia coli (E. coli)
- Purification/Conjugué
- Cette ANGL4 protéine est marqué à la GST tag.
- Application
- SDS-PAGE (SDS)
- Séquence
- VQSKSPRFAS WDEMNVLAHG LLQLGQGLRE HAERTRSQLS ALERRLSACG SACQGTEGST DLPLAPESRV DPEVLHSLQT QLKAQNSRIQ QLFHKVAQQQ RHLEKQHLRI QHLQSQFGLL DHKHLDHEVA KPARRKRLPE MAQPVDPAHN VSRLHRLPRD CQELFQVGER QSGLFEIQPQ GSPPFLVNCK MTSDGGWTVI QRRHDGSVDF NRPWEAYKAG FGDPHGEFWL GLEKVHSITG DRNSRLAVQL RDWDGNAELL QFSVHLGGED TAYSLQLTAP VAGQLGATTV PPSGLSVPFS TWDQDHDLRR DKNCAKSLSG GWWFGTCSHS NLNGQYFRSI PQQRQKLKKG IFWKTWRGRY YPLQATTMLI QPMAAE
- Purification
- SDS-PAGE
- Pureté
- > 90 %
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.1-2 mg/mL
- Buffer
- 20 mM Tris-HCl based buffer, pH 8.0
- Stock
- -80 °C,4 °C,-20 °C
- Stockage commentaire
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- Antigène
- ANGL4 (Angiopoietin-Related Protein 4 (ANGL4))
- Autre désignation
- ANGL4
- Sujet
- Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation .
- Poids moléculaire
- 69.9 kDa
- UniProt
- Q9BY76
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