HIF3A anticorps (AA 581-592)

N° du produit ABIN100475

Détail du produit anti-HIF3A anticorps

Antigène: HIF3A (Hypoxia Inducible Factor 3, alpha Subunit (HIF3A))

Épitope: AA 581-592

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HIF3A est non-conjugé

Application: Western Blotting (WB), ELISA

Attributs du produit: Concentration Definition: by UV absorbance at 280 nm

Stérilité: Sterile filtered

Immunogène: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to aa 581-592 of mouse Hif3 a (Hypoxia Inducible Factor).

Isotype: IgG

Information d'application

Indications d'application: This affinity-purified antibody has been tested for use in ELISA and western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 72 kDa in size corresponding to Hif3 a protein by western blotting in the appropriate cell lysate or extract. This antibody is expected to cross-react with mouse and rat Hif3 a due to sequence homology.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.2 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Références pour anticorps anti-HIF3A (ABIN100475)

Takeda, Ho, Takeda, Duan, Nagy, Fong: "Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2." dans: Molecular and cellular biology, Vol. 26, Issue 22, pp. 8336-46, (2006) (PubMed).

Détails sur HIF3A

Antigène: HIF3A (Hypoxia Inducible Factor 3, alpha Subunit (HIF3A))

Autre désignation: HIF3 alpha (HIF3A Produits)

Synonymes: anticorps HIF-3A, anticorps IPAS, anticorps MOP7, anticorps PASD7, anticorps bHLHe17, anticorps Ipas, anticorps NEPAS, anticorps Mop7, anticorps HIF3A, anticorps hypoxia inducible factor 3 alpha subunit, anticorps hypoxia inducible factor 3, alpha subunit, anticorps HIF3A, anticorps Hif3a

Sujet: One of the most important factors in the cellular response to hypoxia is hypoxia-inducible factor (HIF), which transcriptionally activates genes encoding proteins that mediate adaptive responses to reduced oxygen availability. HIF is a heterodimer consisting of one of three PRIVATE ''TYPE=PICT;ALT={alpha}''subunits (HIF1-aPRIVATE ''TYPE=PICT;ALT={alpha}'', HIF2-a,PRIVATE ''TYPE=PICT;ALT={alpha}'' or HIF3-a)PRIVATE ''TYPE=PICT;ALT={alpha}'' bound to the aryl hydrocarbon receptor nuclear translocator (ARNT) that is also known as HIF1-b. HIF-aPRIVATE ''TYPE=PICT;ALT={alpha}'' is a member of the basic helix-loop-helix (bHLH) superfamily, in which the HLH domain mediates subunit dimerization while the basic domain binds to DNA. HIF target genes play critical roles in metabolism, angiogenesis, cell proliferation, and cell survival; in fact, HIF3-a may be a marker for tumor growth and angiogenesis . Examples of HIF target genes include VEGF, glucose transporter 1 (GLUT1), and EPO. HIF binds to the hypoxia-responsive
Synonyms: HIF3 alpha antibody, HIF3A antibody, Hypoxia Inducible Factor 3 alpha antibody, Hypoxia inducible factor 3 alpha subunit antibody, Hypoxia inducible factor three alpha antibody, Inhibitory PAS domain protein antibody, IPAS antibody

ID gène: 53417, 170295859

UniProt: Q0VBL6

Pathways: L'effet Warburg