KLRK1 anticorps (APC)
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- Antigène Voir toutes KLRK1 Anticorps
- KLRK1 (Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp KLRK1 est conjugé à/à la APC
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Application
- Flow Cytometry (FACS)
- Specificité
- The mouse monoclonal antibody 1D11 recognizes an extracellular epitope of CD314 / NKG2D, a 42 kDa C-type lectin-like activating receptor expressed by NK cells, gamma/delta T cells, and CD8+ T cells.
- Réactivité croisée (Details)
- Human
- Purification
- Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- Immunogène
- NKL cell line
- Clone
- 1D11
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product KLRK1 Anticorps primaire
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- Indications d'application
- Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
- Commentaires
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The purified antibody is conjugated with cross-linked Allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.
- Restrictions
- For Research Use only
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- Reconstitution
- No reconstitution is necessary.
- Buffer
- Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
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Do not freeze.
Avoid prolonged exposure to light. - Stock
- 4 °C
- Stockage commentaire
- Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
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Transient beta-catenin stabilization modifies lineage output from human thymic CD34+CD1a- progenitors." dans: Journal of leukocyte biology, Vol. 87, Issue 3, pp. 405-14, (2010) (PubMed).
: "Self-tolerance of human natural killer cells lacking self-HLA-specific inhibitory receptors." dans: Scandinavian journal of immunology, Vol. 67, Issue 3, pp. 218-29, (2008) (PubMed).
: "Alloreactivity and anti-tumor activity segregate within two distinct subsets of cytokine-induced killer (CIK) cells: implications for their infusion across major HLA barriers." dans: International immunology, Vol. 20, Issue 7, pp. 841-8, (2008) (PubMed).
: "Homing and function of human skin gammadelta T cells and NK cells: relevance for tumor surveillance." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 176, Issue 7, pp. 4331-6, (2006) (PubMed).
: "T cell antigen receptor engagement and specificity in the recognition of stress-inducible MHC class I-related chains by human epithelial gamma delta T cells." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 3, pp. 1236-40, (2002) (PubMed).
: "DAP10 and DAP12 form distinct, but functionally cooperative, receptor complexes in natural killer cells." dans: The Journal of experimental medicine, Vol. 192, Issue 7, pp. 1059-68, (2000) (PubMed).
: "Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA." dans: Science (New York, N.Y.), Vol. 285, Issue 5428, pp. 727-9, (1999) (PubMed).
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Transient beta-catenin stabilization modifies lineage output from human thymic CD34+CD1a- progenitors." dans: Journal of leukocyte biology, Vol. 87, Issue 3, pp. 405-14, (2010) (PubMed).
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- Antigène
- KLRK1 (Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1))
- Autre désignation
- CD314 (KLRK1 Produits)
- Synonymes
- anticorps KLRK1, anticorps NKG2D, anticorps CD314, anticorps D12S2489E, anticorps KLR, anticorps NKG2-D, anticorps D6H12S2489E, anticorps Nkg2d, anticorps Nkrp2, anticorps killer cell lectin like receptor K1, anticorps killer cell lectin-like receptor subfamily K, member 1, anticorps NKG2D protein, anticorps KLRK1, anticorps Klrk1, anticorps NKG2D
- Sujet
- Killer cell lectin like receptor K1,CD314, also known as NKG2D (natural killer receptor G2D) or KLRK1 (killer cell lectin-like receptor subfamily K, member 1), is a homodimeric C-type lectin-like activating receptor and costimulator with type II membrane orientation (C teminus extracellular). CD314 homodimers are associated with DAP10, a membrane adaptor protein that signals similar to CD28 by recruitment of phosphatidylinositol 3-kinase. Engagement of CD314 amplifies antigen-specific T cell responses in CD314-positive T cell populations. In NK cells, CD314 is a primary activating receptor. As CD314 ligands the MHC class-I chain-related proteins A and B (MICA, MICB) and UL16-binding proteins (ULBPs) have been identified.,NKG2D, KLRK1, KLR
- ID gène
- 22914
- UniProt
- P26718
- Pathways
- Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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