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CD79b anticorps (PE)

CD79B Reactivité: Humain FACS Hôte: Souris Monoclonal CB3-1 PE
N° du produit ABIN1027696
  • Antigène Voir toutes CD79b (CD79B) Anticorps
    CD79b (CD79B) (CD79b Molecule, Immunoglobulin-Associated beta (CD79B))
    Reactivité
    • 115
    • 50
    • 17
    • 6
    • 6
    Humain
    Hôte
    • 61
    • 51
    • 14
    • 8
    • 6
    • 2
    • 1
    Souris
    Clonalité
    • 79
    • 58
    • 1
    Monoclonal
    Conjugué
    • 72
    • 17
    • 14
    • 11
    • 9
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CD79b est conjugé à/à la PE
    Application
    • 76
    • 69
    • 41
    • 39
    • 35
    • 11
    • 11
    • 10
    • 10
    • 8
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Flow Cytometry (FACS)
    Specificité
    The mouse monoclonal antibody CB3-1 recognizes an extracellular epitope of CD79b (CD79 beta, Ig beta), an approximately 38 kDa component of B cell receptor (BCR) complex.
    Réactivité croisée (Details)
    Human
    Purification
    Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
    Immunogène
    Fraction of Ig-associated molecules isolated from Ramos B cells
    Clone
    CB3-1
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product CD79B Anticorps primaire
  • Indications d'application
    Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
    Commentaires

    The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.

    Restrictions
    For Research Use only
  • Reconstitution
    No reconstitution is necessary.
    Buffer
    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Do not freeze.
    Avoid prolonged exposure to light.
    Stock
    4 °C
    Stockage commentaire
    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Dornan, Bennett, Chen, Dennis, Eaton, Elkins, French, Go, Jack, Junutula, Koeppen, Lau, McBride, Rawstron, Shi, Yu, Yu, Yue, Zheng, Ebens, Polson: "Therapeutic potential of an anti-CD79b antibody-drug conjugate, anti-CD79b-vc-MMAE, for the treatment of non-Hodgkin lymphoma." dans: Blood, Vol. 114, Issue 13, pp. 2721-9, (2009) (PubMed).

    Zheng, Fuji, Elkins, Yu, Fuh, Chuh, Tan, Hongo, Raab, Kozak, Williams, McDorman, Eaton, Ebens, Polson: "In vivo effects of targeting CD79b with antibodies and antibody-drug conjugates." dans: Molecular cancer therapeutics, Vol. 8, Issue 10, pp. 2937-46, (2009) (PubMed).

    Matutes: "New additions to antibody panels in the characterisation of chronic lymphoproliferative disorders." dans: Journal of clinical pathology, Vol. 55, Issue 3, pp. 180-3, (2002) (PubMed).

    DArena, Cascavilla, Musto, Colella Bisogno, Pistolese, Carotenuto: "CD79b expression in B-cell chronic lymphocytic leukemia." dans: Haematologica, Vol. 85, Issue 5, pp. 556-7, (2000) (PubMed).

    Rassenti, Kipps: "Expression of Ig-beta (CD79b) by chronic lymphocytic leukemia B cells that lack immunoglobulin heavy-chain allelic exclusion." dans: Blood, Vol. 95, Issue 8, pp. 2725-7, (2000) (PubMed).

    Nakamura, Kubagawa, Cooper: "Heterogeneity of immunoglobulin-associated molecules on human B cells identified by monoclonal antibodies." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 18, pp. 8522-6, (1992) (PubMed).

  • Antigène
    CD79b (CD79B) (CD79b Molecule, Immunoglobulin-Associated beta (CD79B))
    Autre désignation
    CD79b (CD79B Produits)
    Synonymes
    anticorps B29, anticorps Ig-beta, anticorps Igb, anticorps Igbeta, anticorps AGM6, anticorps IGB, anticorps CD79B antigen, anticorps CD79b molecule, anticorps Cd79b, anticorps CD79B
    Sujet
    CD79b molecule,CD79b (Ig beta, B29) forms disulfide-linked heterodimer with CD79a (Ig alpha, MB1). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling.,BCR beta, Ig-beta, B29, IGB
    ID gène
    974
    UniProt
    P40259
    Pathways
    BCR Signaling
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