alpha 2 Macroglobulin anticorps

N° du produit ABIN103762

Détail du produit anti-alpha 2 Macroglobulin anticorps

Antigène: alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))

Reactivité: Humain

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp alpha 2 Macroglobulin est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Attributs du produit: Concentration Definition: by UV absorbance at 280 nm

Immunogène: a2-Macroglobulin [Human Plasma]
Immunogentype:Native

Isotype: IgG

Information d'application

Indications d'application: Anti-alpha-2-macroglobulin antibody is suitable for ELISA, Western Blot and Immunohistochemistry applications. Anti-alpha-2-MACROGLOBULIN antibody should be optimized by the end user for the specific reactive conditions.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Restore with deionized water (or equivalent)

Concentration: 10.0 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Références pour anticorps anti-alpha 2 Macroglobulin (ABIN103762)

Chung, Hsu, Chen, Liu, Chang, Li, Huang, Shieh, Lee: "Association of salivary alpha 2-macroglobulin levels and clinical characteristics in type 2 diabetes." dans: Journal of diabetes investigation, Vol. 7, Issue 2, pp. 190-6, (2017) (PubMed).

Détails sur alpha 2 Macroglobulin

Antigène: alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))

Autre désignation: Alpha-2-Macroglobulin (A2M Produits)

Synonymes: anticorps A2MD, anticorps CPAMD5, anticorps FWP007, anticorps S863-7, anticorps A2MAC1, anticorps A2m1, anticorps A2maa, anticorps Mam, anticorps A2mp, anticorps A2M, anticorps LOC733429, anticorps endod, anticorps cpamd5, anticorps fwp007, anticorps s863-7, anticorps a2mb, anticorps endodermin, anticorps Alpha-2-M, anticorps alpha-2-macroglobulin, anticorps pregnancy-zone protein L homeolog, anticorps alpha-2-macroglobulin S homeolog, anticorps pregnancy zone protein, anticorps alpha-2-macroglobulin-like, anticorps A2M, anticorps A2m, anticorps LOC477699, anticorps pzp.L, anticorps AZL_c00450, anticorps LOC100349077, anticorps a2m, anticorps LOC100061656, anticorps LOC100090399, anticorps a2m.S, anticorps LOC100469973, anticorps LOC100595735, anticorps PZP, anticorps LOC100353095, anticorps LOC101122940, anticorps LOC101801552, anticorps LOC100911545

Sujet: Alpha-2-Macroglobulin detects Macroglobulin. Alpha-2-MACROGLOBULIN is a large plasma protein found in the blood. It is produced by the liver, and is a major component of the alpha-2 band in protein electrophoresis. Alpha 2-Macroglobulin is the largest major nonimmunoglobulin protein in plasma. The alpha 2-macroglobulin molecule is synthesized mainly in liver, but also locally by macrophages, fibroblasts, and adrenocortical cells. Alpha 2 macroglobulin acts as an antiprotease and is able to inactivate an enormous variety of proteinases. It functions as an inhibitor of fibrinolysis by inhibiting plasmin and kallikrein. It functions as an inhibitor of coagulation by inhibiting thrombin. Alpha 2-macroglobulin may act as a carrier protein because it also binds to numerous growth factors and cytokines, such as platelet-derived growth factor, basic fibroblast growth factor, TGF-β, insulin, and IL-1β. No specific deficiency with associated disease has been recognized, and no disease state is attributed to low concentrations of Alpha 2 macroglobulin. The concentration of alpha 2 macroglobulin rises 10-fold or more in the nephrotic syndrome when other lower molecular weight proteins are lost in the urine. The loss of alpha 2 macroglobulin into urine is prevented by its large size. The net result is that alpha 2 macroglobulin reaches serum levels equal to or greater than those of albumin in the nephrotic syndrome, which has the effect of maintaining oncotic pressure. Antialpha-2-macroglobulin is ideal for investigators involved in serum component protein research.
Synonyms: A2M antibody, Alpha 2 M antibody, Alpha 2M antibody, CPAMD5 antibody, DKFZp779B086 antibody, FWP007 antibody, S863 7 antibody

ID gène: 2

UniProt: P01023

Pathways: Lipid Metabolism