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SH3BP2 anticorps (pSer427)

SH3BP2 Reactivité: Humain WB, ELISA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN106826
  • Antigène Voir toutes SH3BP2 Anticorps
    SH3BP2 (SH3-Domain Binding Protein 2 (SH3BP2))
    Épitope
    • 7
    • 7
    • 6
    • 6
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 422-433, pSer427
    Reactivité
    • 39
    • 13
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 35
    • 4
    • 1
    Lapin
    Clonalité
    • 38
    • 2
    Polyclonal
    Conjugué
    • 21
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SH3BP2 est non-conjugé
    Application
    • 27
    • 19
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    Attributs du produit
    Concentration Definition: by UV absorbance at 280 nm
    Immunogène
    This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding aa 422-433 of Human SH3BP3 protein (SH3 Domain Binding Protein 2).
    Isotype
    IgG
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    Discover our top product SH3BP2 Anticorps primaire
  • Indications d'application
    This affinity purified antibody has been tested for use in ELISA and by western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 60 kDa in size corresponding to SH3BP2 by western blotting in the appropriate cell lysate or extract.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1.0 mg/mL
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
  • Antigène
    SH3BP2 (SH3-Domain Binding Protein 2 (SH3BP2))
    Autre désignation
    SH3BP2 (SH3BP2 Produits)
    Synonymes
    anticorps SH3BP2, anticorps 3BP-2, anticorps 3BP2, anticorps CRBM, anticorps CRPM, anticorps SH3 domain binding protein 2, anticorps SH3-domain binding protein 2, anticorps SH3BP2, anticorps Sh3bp2
    Sujet
    SH3BP2 Src Homology 3 Binding Protein 2 is also known as 3BP-2 and SH3 Binding Protein 2. The Src homology 3 (SH3) region is a small protein domain presented in a very large group of proteins, including cytoskeletal elements and signaling proteins. SH3 domains are believed to serve as modules that mediate protein-protein associations and, along with Src homology 2 (SH2) domains, regulate cytoplasmic signaling. SH3BP2 is composed of an N terminal pleckstrin homology (PH) domain, a ten aa SH3 binding domain, three modular peptide recognition domains, and a C terminal SH2 domain. SH3BP2 function relates to signal transduction and regulation. SH3BP2 binds differentially to the SH3 domains of certain proteins of signal transduction pathways.   Phosphorylation of SH3BP2 occurs on S427 for activation. SH3BP2 mediates interactions of huntingtin and MLK2 (mixed lineage kinase). Defects in SH3BP2 are the cause of cherubism (CRBM), an autosomal dominant inherited syndrome. It is characterized by excessive bone degradation of the upper and lower jaws, which often begins around three years of age. It is followed by development of fibrous tissue masses, which causes a characteristic facial swelling.
    Synonyms: SH3BP2 Src Homology 3 Binding Protein 2, 3BP-2 and SH3 Binding Protein 2. SH3 domain-binding protein 2 3BP-2
    ID gène
    10825, 170014703
    UniProt
    P78314
    Pathways
    TCR Signaling
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