TLK1 anticorps (Isoform 1)

N° du produit ABIN107632

Détail du produit anti-TLK1 anticorps

Antigène: TLK1 (Tousled-Like Kinase 1 (TLK1))

Épitope: AA 737-751, Isoform 1

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TLK1 est non-conjugé

Application: Western Blotting (WB), ELISA

Attributs du produit: Concentration Definition: by UV absorbance at 280 nm

Immunogène: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 737-751 of human Tlk1 (Tousled-like kinase) protein.

Isotype: IgG

Information d'application

Indications d'application: This affinity purified antibody has been tested for use in ELISA and by western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 86 kDa, 89 kDa or 64 kDa in size corresponding to isoforms of TLk-1 by western blotting in the appropriate cell lysate or extract.  This antibody reacts with both phosphorylated and non-phosphorylated forms of Tlk-1 at the S743 residue (isoform 1) of the protein.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.60 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur TLK1

Antigène: TLK1 (Tousled-Like Kinase 1 (TLK1))

Autre désignation: Tlk1 (TLK1 Produits)

Synonymes: anticorps PKU-beta, anticorps 4930545J15Rik, anticorps fe11e12, anticorps si:dkey-251e16.4, anticorps tlk1, anticorps wu:fe11e12, anticorps TLK1, anticorps fb76h12, anticorps si:dkey-88m1.1, anticorps wu:fb76h12, anticorps DKFZp459L163, anticorps tousled like kinase 1, anticorps tousled-like kinase 1, anticorps tousled-like kinase 1b, anticorps tousled like kinase 1 like, anticorps serine/threonine-protein kinase TOUSLED, anticorps tousled-like kinase 1a, anticorps Serine/threonine-protein kinase tousled-like 1, anticorps TLK1, anticorps Tlk1, anticorps tlk1b, anticorps TLK1L, anticorps LOC542181, anticorps tlk1a, anticorps tlk1, anticorps tlk-1

Sujet: Tlk-1 (also known as tousled-like kinase, serine/threonine-protein kinase tousled-like 1 and PKU-beta) is a target for Chk1 upon induction of DNA-damage. Tousled-like kinases, first described in Arabadopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly. Tlk-1 is rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent.  Tlk-1 heterodimerizes with Tlk-2.  Multiple isoforms of the protein have been detected.  Mature Tlk-1 is reported to have an apparent molecular weight of ~86kDa, ~89kDa and ~64kDa corresponding to isoforms 1, 2 and 3 respectively.
Synonyms: PKU beta antibody, serine threonine protein kinase antibody, Serine/threonine protein kinase tousled like 1 antibody, TLK1 antibody, Tousled like kinase 1 antibody

ID gène: 9874, 33636698

UniProt: Q9UKI8