CHCHD6 anticorps (N-Term)
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- Antigène Voir toutes CHCHD6 Anticorps
- CHCHD6 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 6 (CHCHD6))
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Épitope
- N-Term
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp CHCHD6 est non-conjugé
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Application
- Western Blotting (WB), ELISA
- Specificité
- CHCHD6 is predicted to not cross-react to other members of the CHCHD family.
- Purification
- Affinity chromatography purified via peptide column
- Immunogène
- Rabbit polyclonal CHCHD6 antibody was raised against a 17 amino acid peptide near the amino terminus of human CHCHD6.
- Isotype
- IgG
- Top Product
- Discover our top product CHCHD6 Anticorps primaire
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- Indications d'application
- CHCHD6 antibody can be used for detection of CHCHD6 by Western blot at 1 - 2 μg/mL.
- Commentaires
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(NT) Coiled-coil-helix-coiled-coil-helix domain-containing protein 6
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS containing 0.02 % Sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Stock
- 4 °C
- Stockage commentaire
- CHCHD6 antibody can be stored at 4 °C for three months. At -20 °C stable for up to one year.
- Date de péremption
- 12 months
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- Antigène
- CHCHD6 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 6 (CHCHD6))
- Autre désignation
- CHCHD6 (CHCHD6 Produits)
- Synonymes
- anticorps CHCM1, anticorps PPP1R23, anticorps 0710001P09Rik, anticorps 1700021B03Rik, anticorps chchd6, anticorps hm:zeh0124, anticorps zgc:91802, anticorps coiled-coil-helix-coiled-coil-helix domain containing 6, anticorps coiled-coil-helix-coiled-coil-helix domain containing 6a, anticorps CHCHD6, anticorps Chchd6, anticorps chchd6a
- Sujet
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CHCHD6 is a member of a family of proteins containing a conserved (coiled coil 1)-(helix 1)-(coiled coil 2)-(helix 2) domain and has been observed in a complex with the mitochondrial proteins mitofilin, SAM50, metaxins 1 and 2, and CHCHD3. CHCHD6 knockdown causes severe defects in mitochondrial cristae morphology as well as reductions in cell growth, ATP production and oxygen consumption. This decrease of CHCHD6 also led to a reduction in mitofilin protein levels, while a knockdown of mitofilin resulted in a reduced level of CHCHD6, suggesting coordinate regulation between these two proteins. CHCHD6 knockdown in human cancer cells enhances their sensitivity to genotoxic anticancer drugs, suggesting that CHCHD6 may be a potential therapeutic anti-tumor target.
Synonyms: Coiled-coil-helix-coiled-coil-helix domain-containing protein 6, coiled coil helix cristae morphology 1, CHCM1, PPP1R23 - Poids moléculaire
- 26 kDa (calculated)
- ID gène
- 84303
- NCBI Accession
- NP_115719
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