PIK3R1 anticorps (AA 159-388)

N° du produit ABIN1098111

Détail du produit anti-PIK3R1 anticorps

Antigène: PIK3R1 (PI3K p85a) (Phosphoinositide 3 Kinase, p85 alpha (PI3K p85a))

Épitope: AA 159-388

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PIK3R1 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Fonction: PIK3R1 Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human PIK3R1 (AA: 159-388) expressed in E. Coli.

Clone: 6G10

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-PIK3R1 (ABIN1098111)

Natunen, Martiskainen, Marttinen, Gabbouj, Koivisto, Kemppainen, Kaipainen, Takalo, Svobodová, Leppänen, Kemiläinen, Ryhänen, Kuulasmaa, Rahunen, Juutinen, Mäkinen, Miettinen, Rauramaa, Pihlajamäki et al.: "Diabetic phenotype in mouse and humans reduces the number of microglia around β-amyloid plaques. ..." dans: Molecular neurodegeneration, Vol. 15, Issue 1, pp. 66, (2020) (PubMed).

Kwon, Salinas, Kolb, Fu, Feng, Stanford, Ostrander: "Genetic polymorphisms in inflammation pathway genes and prostate cancer risk." dans: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 20, Issue 5, pp. 923-33, (2011) (PubMed).

Taniguchi, Winnay, Kondo, Bronson, Guimaraes, Alemán, Luo, Stephanopoulos, Weissleder, Cantley, Kahn: "The phosphoinositide 3-kinase regulatory subunit p85alpha can exert tumor suppressor properties through negative regulation of growth factor signaling." dans: Cancer research, Vol. 70, Issue 13, pp. 5305-15, (2010) (PubMed).

Détails sur PIK3R1

Antigène: PIK3R1 (PI3K p85a) (Phosphoinositide 3 Kinase, p85 alpha (PI3K p85a))

Autre désignation: PIK3R1 (PI3K p85a Produits)

Synonymes: anticorps PI3CG, anticorps PI3K, anticorps PI3Kgamma, anticorps PIK3, anticorps AGM7, anticorps GRB1, anticorps p85, anticorps p85-ALPHA, anticorps PI3KA, anticorps AA414921, anticorps C530050K14, anticorps p50alpha, anticorps p55alpha, anticorps p85alpha, anticorps wu:fb65b05, anticorps phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma, anticorps phosphoinositide-3-kinase regulatory subunit 1, anticorps phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta, anticorps phosphoinositide-3-kinase, regulatory subunit 1 (alpha), anticorps PIK3CG, anticorps PIK3R1, anticorps Pik3r1, anticorps Pik3cb, anticorps pik3r1

Sujet:

Description: Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms.

Aliases: p85, GRB1, p85-ALPHA

Poids moléculaire: 83.6kDa

ID gène: 5295

HGNC: 5295

UniProt: P27986

Pathways: TCR Signaling, Response to Growth Hormone Stimulus, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Hepatitis C, Protein targeting to Nucleus, VEGF Signaling, BCR Signaling, L'effet Warburg