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HAS2 anticorps (AA 67-170)

HAS2 Reactivité: Humain ELISA, WB, IHC, ICC Hôte: Souris Monoclonal 4E7 unconjugated
N° du produit ABIN1098124
  • Antigène Voir toutes HAS2 Anticorps
    HAS2 (Hyaluronan Synthase 2 (HAS2))
    Épitope
    • 7
    • 5
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 67-170
    Reactivité
    • 42
    • 20
    • 14
    Humain
    Hôte
    • 35
    • 12
    Souris
    Clonalité
    • 35
    • 12
    Monoclonal
    Conjugué
    • 14
    • 6
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp HAS2 est non-conjugé
    Application
    • 31
    • 18
    • 13
    • 11
    • 9
    • 6
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)
    Fonction
    HAS2 Antibody
    Purification
    Purified antibody
    Immunogène
    Purified recombinant fragment of human HAS2 (AA: 67-170) expressed in E. Coli.
    Clone
    4E7
    Isotype
    IgG1
  • Indications d'application

    ELISA: 1/10000

    ICC: 1/100 - 1/500

    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified antibody in PBS with 0.05 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Okuda, Kobayashi, Xia, Watabe, Pai, Hirota, Xing, Liu, Pandey, Fukuda, Modur, Ghosh, Wilber, Watabe: "Hyaluronan synthase HAS2 promotes tumor progression in bone by stimulating the interaction of breast cancer stem-like cells with macrophages and stromal cells." dans: Cancer research, Vol. 72, Issue 2, pp. 537-47, (2012) (PubMed).

    Jokela, Makkonen, Oikari, Kärnä, Koli, Hart, Tammi, Carlberg, Tammi: "Cellular content of UDP-N-acetylhexosamines controls hyaluronan synthase 2 expression and correlates with O-linked N-acetylglucosamine modification of transcription factors YY1 and SP1." dans: The Journal of biological chemistry, Vol. 286, Issue 38, pp. 33632-40, (2011) (PubMed).

  • Antigène
    HAS2 (Hyaluronan Synthase 2 (HAS2))
    Autre désignation
    HAS2 (HAS2 Produits)
    Synonymes
    anticorps DG42, anticorps XHas2, anticorps Has2, anticorps hyaluronan synthase 2, anticorps hyaluronan synthase 2 S homeolog, anticorps has2, anticorps HAS2, anticorps Has2, anticorps SHAS2, anticorps has2.S
    Sujet
    Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1.
    Poids moléculaire
    63.5kDa
    ID gène
    3037
    HGNC
    3037
    UniProt
    Q92819
    Pathways
    Glycosaminoglycan Metabolic Process
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