Prosaposin anticorps (AA 325-524)
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- Antigène Voir toutes Prosaposin (PSAP) Anticorps
- Prosaposin (PSAP)
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Épitope
- AA 325-524
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp Prosaposin est non-conjugé
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Application
- Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)
- Fonction
- PSAP Antibody
- Purification
- Purified antibody
- Immunogène
- Purified recombinant fragment of human PSAP (AA: 325-524 ) expressed in E. Coli.
- Clone
- 4D5F4
- Isotype
- IgG1
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- Indications d'application
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ELISA: 1/10000
FCM: 1/200 - 1/400
ICC: 1/50 - 1/500
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified antibody in PBS with 0.05 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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The interaction of the second Kunitz-type domain (KD2) of TFPI-2 with a novel interaction partner, prosaposin, mediates the inhibition of the invasion and migration of human fibrosarcoma cells." dans: The Biochemical journal, Vol. 441, Issue 2, pp. 665-74, (2011) (PubMed).
: "Prosaposin down-modulation decreases metastatic prostate cancer cell adhesion, migration, and invasion." dans: Molecular cancer, Vol. 9, pp. 30, (2010) (PubMed).
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The interaction of the second Kunitz-type domain (KD2) of TFPI-2 with a novel interaction partner, prosaposin, mediates the inhibition of the invasion and migration of human fibrosarcoma cells." dans: The Biochemical journal, Vol. 441, Issue 2, pp. 665-74, (2011) (PubMed).
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- Antigène
- Prosaposin (PSAP)
- Autre désignation
- PSAP (PSAP Produits)
- Synonymes
- anticorps GLBA, anticorps SAP1, anticorps AI037048, anticorps SGP-1, anticorps SGP1A, anticorps cb759, anticorps wu:fa14a06, anticorps wu:fb36e02, anticorps wu:fb58g07, anticorps PSAP, anticorps PSP-A, anticorps SFTPA1B, anticorps SP-A, anticorps prosaposin, anticorps surfactant protein A1, anticorps PSAP, anticorps Psap, anticorps psap, anticorps LOC100011417, anticorps LOC100304726, anticorps LOC100526719, anticorps SFTPA1
- Sujet
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Description: This gene encodes a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease, Tay-Sachs disease, and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants encoding different isoforms.
Aliases: GLBA, SAP1
- Poids moléculaire
- 58.1kDa
- ID gène
- 5660
- HGNC
- 5660
- UniProt
- P07602
- Pathways
- Positive Regulation of Endopeptidase Activity
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