Acetylated Lysine anticorps (acetylated)
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- Antigène Tous les produits Acetylated Lysine
- Acetylated Lysine
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Épitope
- acetylated
- Reactivité
- Veuillez nous consulter SVP
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp Acetylated Lysine est non-conjugé
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Application
- Western Blotting (WB), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Purification
- Affinity Chromatography on Protein G
- Clone
- 7F8
- Isotype
- IgG1
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- PBS, pH 7.4 containing 0.09 % Sodium Azide in 50 % Glycerol
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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- Antigène
- Acetylated Lysine
- Abstract
- Acetylated Lysine Produits
- Synonymes
- anticorps C-K-RAS, anticorps CFC2, anticorps K-RAS2A, anticorps K-RAS2B, anticorps K-RAS4A, anticorps K-RAS4B, anticorps KI-RAS, anticorps KRAS1, anticorps KRAS2, anticorps NS, anticorps NS3, anticorps RASK2, anticorps KRAS proto-oncogene, GTPase, anticorps KRAS
- Classe de substances
- Chemical
- Sujet
- Post-translational modifications of proteins play critical roles in the regulation and function of many known biological processes. Proteins can be post-translationally modified in many different ways, and a common posttranscriptional modification of Lysine involves acetylation (1). The conserved amino-terminal domains of the four core histones (H2A, H2B, H3 and H4) contain lysines that are acetylated by histone acetyltransferases (HATs) and deacetylated by histone deacetylases (HDACs) (2). Protein posttranslational reversible lysine N?-acetylation and deacetylation have been recognized as an emerging intracellular signaling mechanism that plays critical roles in regulating gene transcription, cell-cycle progression, apoptosis, DNA repair, and cytoskeletal organization (3). The regulation of protein acetylation status is impaired in the pathologies of cancer and polyglutamine diseases (4), and HDACs have become promising targets for anticancer drugs currently in development (5).Synonyms: AcK, acetyl Lysine, acetyl-Lysine
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