Carboxy Methyl Lysine anticorps

N° du produit ABIN1105660

Détail du produit anti-Carboxy Methyl Lysine anticorps

Antigène: Carboxy Methyl Lysine (CML)

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Carboxy Methyl Lysine est non-conjugé

Application: Enzyme Immunoassay (EIA), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF)

Réactivité croisée (Details): Species reactivity (tested):Human, Multispecies cross reactant.

Purification: Protein G Chromatography

Immunogène: Carboxy Methyl Lysine (CML)-KLH

Clone: CML26

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.1 mg/mL

Buffer: PBS, 0.02 % Sodium Azide, 0.1 % BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store undiluted at 2-8 °C.

Détails sur Carboxy Methyl Lysine

Antigène: Carboxy Methyl Lysine (CML)

Autre désignation: Carboxy Methyl Lysine (CML Produits)

Synonymes: anticorps ALL, anticorps BCR1, anticorps CML, anticorps D22S11, anticorps D22S662, anticorps PHL, anticorps BCR, RhoGEF and GTPase activating protein, anticorps BCR

Classe de substances: Amino Acid

Sujet: CML is known to be formed from the oxidation of both carbohydrates and lipids. This makes CML a biomarker of general oxidative stress. Carboxymethyl-lysine (CML) is a well-characterized glycoxidation product that accumulates in tissues with age, and its rate of accumulation is accelerated in diabetes. Glycoxidation products are a subset of advanced glycation endproducts (AGEs) that are formed by the nonenzymatic glycation and subsequent irreversible oxidation of proteins. Oxidative stress and protein modification have been implicated in the pathogenesis of the chronic complications of diabetes, including nephropathy and atherosclerosis. The accumulation of CML in long-lived tissue such as skin collagen reflects oxidative stress over an extended period of the life-span, and has been shown to be greater in patients with diabetic complications than those without complications.Synonyms: CML, Carboxymethyl-lysine