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CBLL1 anticorps
CBLL1
Reactivité: Humain
WB, IF, IHC (fro)
Hôte: Lapin
Polyclonal
unconjugated
N° du produit ABIN1105708
Détail du produit anti-CBLL1 anticorps
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Antigène
Voir toutes CBLL1 Anticorps
CBLL1
(Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence-Like 1 (CBLL1))
Reactivité
Toutes les réactivités sur CBLL1 Anticorps
Humain
Hôte
Toutes les hôtes sur CBLL1 Anticorps
Lapin
Clonalité
Toutes les clonalités sur CBLL1 Anticorps
Polyclonal
Conjugué
Tous les conjugués à travers CBLL1 Anticorps
Cet anticorp CBLL1 est non-conjugé
Application
Tous les applications à travers CBLL1 Anticorps.
Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))
Specificité
This antibody reacts with human Hakai, a c-Cbl-like protein.
Réactivité croisée (Details)
Species reactivity (tested):Human
Purification
Protein A
Isotype
IgG
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Alternatives
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Information d'application
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Indications d'application
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Stockage
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Concentration
0.1 mg/mL
Buffer
PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C
Stockage commentaire
Store at 2 - 8 °C.
Détails sur CBLL1
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Antigène
CBLL1
(Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence-Like 1 (CBLL1))
Autre désignation
CBLL1 / RNF188 (CBLL1 Produits )
Synonymes
anticorps HAKAI, anticorps RNF188, anticorps zgc:55308, anticorps CBLL1, anticorps AI467391, anticorps Hakai, anticorps c-Cbl-like, anticorps cbll1, anticorps hakai, anticorps rnf188, anticorps Cbl proto-oncogene like 1, anticorps Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase S homeolog, anticorps Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase, anticorps Casitas B-lineage lymphoma-like 1, anticorps Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase L homeolog, anticorps CBLL1, anticorps cbll1.S, anticorps Cbll1, anticorps cbll1, anticorps cbll1.L
Sujet
Hakai is an E-cadherin binding protein, which has been identified as an E3 ubiquitin-ligase. Hakai contains SH2, RING, zinc-finger and proline-rich domains. Hakai interacts with E-cadherin in a tyrosine phosphorylation-dependent manner, inducing ubiquitination of the E-cadherin complex. Expression of Hakai in epithelial cells disrupts cell-cell contacts and enhances endocytosis of E-cadherin and cell motility. By promoting the endocytosis and dynamic recycling or destruction of E-cadherin complexes, Hakai is able to control epithelial-mesenchymal transitions under physiological and pathological conditions.Synonyms: Casitas B-lineage lymphoma-transforming sequence-like protein 1, E3 ubiquitin-protein ligase Hakai, HAKAI, RING finger protein 188, c-Cbl-like protein 1
ID gène
79872
NCBI Accession
NP_079090
UniProt
Q75N03
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