CKB anticorps (N-Term)
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- Antigène Voir toutes CKB Anticorps
- CKB (Creatine Kinase, Brain (CKB))
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Épitope
- N-Term
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Reactivité
- Humain, Souris, Rat, Lapin
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp CKB est non-conjugé
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Application
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Séquence
- SNSHNALKLR FPAEDEF
- Specificité
- The monoclonal antibody CK-BYK/21E10 recognizes creatine kinase B-type, also known as CKB.
- Réactivité croisée (Details)
- Species reactivity (tested):Human, mouse, rat, rabbit
- Purification
- Protein G
- Immunogène
- Synthetic 17-mer peptide corresponding to the N-terminal sequence of human creatine kinase brain-type
- Clone
- CK-BYK-21E10
- Isotype
- IgG2b
- Top Product
- Discover our top product CKB Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 0.1 mg/mL
- Buffer
- PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C
- Stockage commentaire
- Store at 2 - 8 °C.
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- Antigène
- CKB (Creatine Kinase, Brain (CKB))
- Autre désignation
- CKBB (CKB Produits)
- Synonymes
- anticorps B-CK, anticorps CKBB, anticorps b-ck, anticorps ckbb, anticorps CKB, anticorps Bck, anticorps Ck-3, anticorps Ck3, anticorps Ckbb, anticorps bck, anticorps ckb, anticorps cb594, anticorps wu:fj36f10, anticorps wu:fj37d11, anticorps Ckbr, anticorps mg:cb02h12, anticorps wu:fb62d04, anticorps wu:fc14g11, anticorps zgc:154095, anticorps zgc:92079, anticorps creatine kinase B, anticorps creatine kinase, brain L homeolog, anticorps creatine kinase B-type, anticorps creatine kinase, brain, anticorps creatine kinase, brain b, anticorps creatine kinase, brain a, anticorps CKB, anticorps ckb.L, anticorps Ckb, anticorps ckb, anticorps ckbb, anticorps ckba
- Sujet
- Human CKB is a protein of 381 amino acids (~45 kDa), expressed in a number of tissues. CKB is most abundant in adult brain, approx. 5-fold lower in the stomach, 10-fold lower in the heart and barely detectable in liver. In brain, whereas most CKB has been shown to be cytosolic, several of the reactions requiring CKB are membrane-associated. CKB belongs to the creatine kinase (CK) isoenzymes that catalyse the synthesis of phosphocreatine (PCr) and its subsequent use in the regeneration of ATP in cell types where the consumption of ATP is rapid and/or sudden. In the brain the different CK isoforms constitute an energy shuttle wherein ATP produced in the mitochondria is used by a mitochondrial CK [e.g. ubiquitous mitochondrial creatine kinase (uMi-CK)] to generate PCr, which is then transported and used by a cytoplasmic CK [e.g. brain creatine kinase (CKB)] to regenerate ATP at discrete cellular sites of high ATP turnover. CKB appears to have a role in regenerating ATP needed for the transport of ions and neurotransmitters since CKB has been localized to brain synaptic plasma membranes, possibly coupled to Na+/K+-ATPase and acetylcholine receptor-rich membranes. Expression of CKB is developmentally controlled: in rat, brain CKB protein at birth is extremely low and increases 10-fold until week 4. This reflects the many energy-demanding processes in brain during brain development.Synonyms: B-CK, CKB, Creatine kinase B chain, Creatine kinase B-type, Creatine kinase BB
- ID gène
- 1152
- NCBI Accession
- NP_001814
- UniProt
- P12277
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