HLA-DMA anticorps

N° du produit ABIN1107564

Détail du produit anti-HLA-DMA anticorps

Antigène: HLA-DMA (Major Histocompatibility Complex, Class II, DM alpha (HLA-DMA))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp HLA-DMA est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Flow Cytometry (FACS), Functional Studies (Func), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificité: The antibody reacts with murine MHC class II glycoproteins. It recognizes a shared determinant on I-Ab, I-Ad, I-Aq, and I-Ed, I-Ek alloantigens, but it does not react with I-Af, I-Ak, I-As. This antibody can inhibit I-A-restricted T cell responses of the H-2b, H-2d, H-2q, H-2u but not H-2f, H-2k, H-2s haplotypes.

Réactivité croisée (Details): Species reactivity (tested):Mouse

Purification: Protein-G affinity chromatography

Pureté: > 95 % pure by SDS-PAGE

Immunogène: Activated C57BL/6 mouse spleen cells

Clone: M5-114

Isotype: IgG2b

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Azide free phosphate buffered saline (PBS), approx. pH 7.4, 0.2 μm filter sterilized

Agent conservateur: Azide free

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.

Détails sur HLA-DMA

Antigène: HLA-DMA (Major Histocompatibility Complex, Class II, DM alpha (HLA-DMA))

Abstract: HLA-DMA Produits

Synonymes: anticorps RT1.Ma, anticorps RT1.DMa, anticorps HLA-DMA, anticorps H-2Ma, anticorps H2-Ma, anticorps D6S222E, anticorps DMA, anticorps HLADM, anticorps RING6, anticorps RT1 class II, locus DMa, anticorps SLA-DM alpha chain, anticorps major histocompatibility complex, class II, DM alpha, anticorps histocompatibility 2, class II, locus DMa, anticorps RT1-DMa, anticorps SLA-DMA, anticorps DLA-DMA, anticorps H2-DMa, anticorps HLA-DMA

Sujet: MHC (major histocompatibility complex) class II molecules are transmembrane glycoproteins expressed on the surface of professional antigen-presenting cells, such as macrophages, dendritic cells and B cells. Before their exposition on the cell surface, the MHC class II molecules react with endocytosed exogenous antigens, which are then presented to the T cells. The antigen-binding grove between MHC class II alpha and beta chain is open at both ends and is 15-24 amino acid residues long.Synonyms: DM alpha chain, DMA, HLA class II histocompatibility antigen, MHC class II antigen DMA, RING6, Really interesting new gene 6 protein

ID gène: 3108

NCBI Accession: NP_006111

UniProt: P28067

Pathways: Cancer Immune Checkpoints, Human Leukocyte Antigen (HLA) in Adaptive Immune Response