HTRA2 anticorps

N° du produit ABIN1107619

Détail du produit anti-HTRA2 anticorps

Antigène: HTRA2 (HtrA Serine Peptidase 2 (HTRA2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp HTRA2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)

Specificité: This antibody reacts with HtrA2/Omi (40 kDa) on Western blotting.

Purification: Protein-A Agarose Chromatography of hybridoma supernatant.

Immunogène: Human recombinant 6His tagged HtrA2/Omi.

Clone: 18-01-83

Isotype: IgG2a

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.2 containing 50 % Glycerol without preservatives.

Agent conservateur: Without preservative

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody (in aliquots) at -20 °C.

Références pour anticorps anti-HTRA2 (ABIN1107619)

Chung, Islam, Rahman, Hong: "Neuroprotective function of Omi to α-synuclein-induced neurotoxicity." dans: Neurobiology of disease, Vol. 136, pp. 104706, (2021) (PubMed).

Détails sur HTRA2

Antigène: HTRA2 (HtrA Serine Peptidase 2 (HTRA2))

Autre désignation: HTRA2 / PRSS25 (HTRA2 Produits)

Synonymes: anticorps CG8464, anticorps DmHtrA2, anticorps Dmel\\CG8464, anticorps HtrA2/Omi, anticorps Omi, anticorps dOmi, anticorps domi, anticorps htrA2, anticorps omi, anticorps HTRA2, anticorps PRSS25, anticorps OMI, anticorps PARK13, anticorps AI481710, anticorps Prss25, anticorps mnd2, anticorps HTRA2-related serine protease, anticorps HtrA serine peptidase 2, anticorps HtrA2, anticorps HTRA2, anticorps htra2, anticorps Htra2

Sujet: HtrA2, also known as Omi or Serine Protease-25, is a trimeric chaperone/heat shock protein involved in the degradation of aberrantly folded proteins during cellular stress. The ubiquitous HtrA2 protein exists as two isoforms of 38 and 40 kDa and as an alternatively spliced form called D-Omi, which is predominately expressed in the kidney, colon and thyroid. HtrA2 appears to function in the progression of arthritis, aging, and tumor progression. During apoptosis, HtrA2 is released from mitochondria into the cytoplasm where it inhibits XIAP, a caspase inhibitor. Release of HtrA2 from mitochondria appears to require Bax and Bcl-2, and the resulting overexpression of HtrA2 into the cytoplasm induces caspase-independent apoptosis.Synonyms: High temperature requirement protein A2, OMI, Omi stress-regulated endoprotease, Serine protease 25, Serine proteinase OMI, mitochondrial Serine protease HTRA2

ID gène: 27429

NCBI Accession: NP_037379

UniProt: O43464

Pathways: Positive Regulation of Endopeptidase Activity