IL27 anticorps

N° du produit ABIN1107834

Détail du produit anti-IL27 anticorps

Antigène: IL27 (Interleukin-27 Subunit alpha (IL27))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IL27 est non-conjugé

Application: Flow Cytometry (FACS)

Specificité: Recognizes both natural and recombinant Human IL-27

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Ion Exchange Chromatography.

Stérilité: 0.22 μm filtered

Immunogène: Recombinant Human IL-27.

Clone: B-G49

Isotype: IgG2a

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate-buffered saline without Carrier and preservatives. This prodcut is sterile-filtered through 0.22 μm and treated to remove Endotoxins.

Agent conservateur: Without preservative

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur IL27

Antigène: IL27 (Interleukin-27 Subunit alpha (IL27))

Autre désignation: Interleukin-27 / IL27A (IL27 Produits)

Sujet: Like interleukin-23 (IL-23), IL-27 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the p40-related protein EBI3 and an IL-12 p35-related protein termed p28. IL-27 is produced after activation by antigen-presenting cells and induces proliferation of naive but not memory CD4+ T-cells. It acts by binding to its receptor WSX-1 and gp130 which results in the activation of a Jak/STAT signaling cascade, suggesting the IL-27 is involved in the regulation of immune processes. It has been suggested that IL-27 can also be used as a therapeutic agent against cancer as it can also induce tumor-specific anti-tumor activity mediated through CD8+ T-cells, IFN-gamma, and T-bet.Synonyms: IL-27 subunit alpha, IL-30, IL27-A, IL30, Interleukin-30, p28

ID gène: 246778

NCBI Accession: NP_663634

UniProt: Q8NEV9