Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Concentration
0.2 mg/mL
Buffer
0.02 % Sodium Azide
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C
Stockage commentaire
Store undiluted at 2-8 °C.
Droeser, Hirt, Viehl, Frey, Nebiker, Huber, Zlobec, Eppenberger-Castori, Tzankov, Rosso, Zuber, Muraro, Amicarella, Cremonesi, Heberer, Iezzi, Lugli, Terracciano, Sconocchia, Oertli, Spagnoli et al.: "Clinical impact of programmed cell death ligand 1 expression in colorectal cancer. ..." dans: European journal of cancer (Oxford, England : 1990), Vol. 49, Issue 9, pp. 2233-42, (2014) (PubMed).
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Hashimoto, Tabuchi, Sakurai, Kutsuna, Kurokawa, Awasaki, Sekimizu, Nakanishi, Shiratsuchi: "Identification of lipoteichoic acid as a ligand for draper in the phagocytosis of Staphylococcus aureus by Drosophila hemocytes." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 11, pp. 7451-60, (2009) (PubMed).
Jimenez-Dalmaroni, Xiao, Corper, Verdino, Ainge, Larsen, Painter, Rudd, Dwek, Hoebe, Beutler, Wilson: "Soluble CD36 ectodomain binds negatively charged diacylglycerol ligands and acts as a co-receptor for TLR2." dans: PLoS ONE, Vol. 4, Issue 10, pp. e7411, (2009) (PubMed).
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Henneke, Morath, Uematsu, Weichert, Pfitzenmaier, Takeuchi, Müller, Poyart, Akira, Berner, Teti, Geyer, Hartung, Trieu-Cuot, Kasper, Golenbock: "Role of lipoteichoic acid in the phagocyte response to group B streptococcus." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 174, Issue 10, pp. 6449-55, (2005) (PubMed).
Triantafilou, Manukyan, Mackie, Morath, Hartung, Heine, Triantafilou: "Lipoteichoic acid and toll-like receptor 2 internalization and targeting to the Golgi are lipid raft-dependent." dans: The Journal of biological chemistry, Vol. 279, Issue 39, pp. 40882-9, (2004) (PubMed).
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LTA, a glycerol phosphate surface polymer, is a component of the envelope of Gram-positive bacteria. LTA is anchored via its glycolipids to the membrane and carries a polysaccharide chain extending into the peptidoglycan layer of the cell wall. LTA is released spontaneously into the culture medium during growth of gram-positive bacteria. LTA functions as an immune activator with characteristics very similar to lipopolysaccharide (LPS) from Gram-negative bacteria. LTA binds to CD14 and triggers activation predominantly via Toll-like receptor 2. Although LTA is internalized and traffics to the Golgi, the cellular activation in response to LTA occurs at the cell surface.