MVP anticorps
-
- Antigène Voir toutes MVP Anticorps
- MVP (Major Vault Protein (MVP))
-
Reactivité
- Humain
-
Hôte
- Souris
-
Clonalité
- Monoclonal
-
Conjugué
- Cet anticorp MVP est non-conjugé
-
Application
- Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Specificité
- This Monoclonal antibody clone 1011 is specific for a 104- kDa protein. This mAb is one of four mAb which recognize different epitopes of the protein. Cells whose supernatant showed a positive signal for a 104- kDa band were selected and cloned by limited dilution.
- Réactivité croisée (Details)
- Species reactivity (tested):Human.
- Purification
- Purified
- Immunogène
- A BALB/c mouse was immunized with 5 myg of affinity purified nuclear extract proteins. Spleen cells were fused with equal number of Sp0Ag-14 myeloma cells.
- Clone
- 1011
- Isotype
- IgG1
- Top Product
- Discover our top product MVP Anticorps primaire
-
-
- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
-
- Concentration
- 0.1 mg/mL
- Buffer
- PBS, 0.05 % Sodium Azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
-
- Antigène
- MVP (Major Vault Protein (MVP))
- Autre désignation
- Major Vault Protein (MVP Produits)
- Synonymes
- anticorps LRP, anticorps VAULT1, anticorps 2310009M24Rik, anticorps cb771, anticorps wu:fb52b05, anticorps wu:fc02g01, anticorps mvp, anticorps MGC145641, anticorps Tb05.45E22.810, anticorps major vault protein, anticorps major vault protein L homeolog, anticorps putative major vault protein, anticorps MVP, anticorps Mvp, anticorps mvp, anticorps mvp.L, anticorps Tc00.1047053510353.10, anticorps Tb927.5.4460, anticorps Tb10.70.0520, anticorps Tb10.70.5840, anticorps LMJF_05_0060
- Sujet
- MVP is identical to lung-resistance related protein (LRP). Vaults are large ribonucleoprotein particles (RNPs) present in all eukaryotic cells. They have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for >70 % of their mass. Their shape is reminiscent of the nucleopore central plug. Amino acid 241-280 of human estrogen receptor (ER), (site of nuclear localization signal sequence), is mapped to be the site of interaction between ER and MVP. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. Anti-estrogen 1C1182 shows no effect. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to progesterone and glucocorticoid receptors are also able to co-immunoprecipitate the MVP. LRP is a protein overexpressed in many neoplastic tissues and cell lines. Expression of LRP predicts a poor response to chemotherapy.This 104-kD protein is the major vault protein (MVP) also described as the lung resistance protein (LRP) and has shown to interact with the estrogen receptor. The protein is part of a very large vault ribonucleoprotein complex present in all eukaryotic cells and its structure and protein composition is highly conserved. Because of the size, shape, and protein and RNA composition of this complex the particles are different from other ribonucleoproteins.Synonyms: LRP, Lung-Resistance Related Protein, MVP
- ID gène
- 9961
- NCBI Accession
- NP_005106
- UniProt
- Q14764
-