MBP/MBL anticorps

N° du produit ABIN1108115

Détail du produit anti-MBP/MBL anticorps

Antigène: MBP/MBL (Mannan Binding Protein/Mannan Binding Lectin (MBP/MBL))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp MBP/MBL est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA), Immunofluorescence (IF)

Réactivité croisée (Details): Species reactivity (tested):Mouse

Purification: Protein G

Immunogène: Purified MBL-C

Clone: 14D12

Isotype: IgG2a

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.1 mg/mL

Buffer: PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store at 2 - 8 °C.

Détails sur MBP/MBL

Antigène: MBP/MBL (Mannan Binding Protein/Mannan Binding Lectin (MBP/MBL))

Autre désignation: Mannan Binding Protein (MBP/MBL Produits)

Synonymes: anticorps COLEC1, anticorps HSMBPC, anticorps MBL, anticorps MBL2D, anticorps MBP, anticorps MBP-C, anticorps MBP1, anticorps MBPD, anticorps pMBP-27, anticorps MBL1, anticorps cMBl, anticorps collectin, anticorps L-MBP, anticorps MBL-C, anticorps RaRF p28A, anticorps mbl, anticorps mannose binding lectin 2, anticorps mannose-binding lectin (protein C) 2, anticorps mannose-binding protein C-like, anticorps MBL2, anticorps Mbl2, anticorps LOC100911854

Sujet: Mannose binding lectin (MBL), also called mannose- or mannan-binding protein (MBP), is a member of the group of collectins. MBL is an important pattern-recognition receptor in the innate immune system. The protein mediates innate immune responses, such as activation of the complement lectin pathway and phagocytosis, to help fight infections. MBL is an oligomeric lectin that recognizes carbohydrates as mannose and N-acetylglucosamine on pathogens. MBL contains a cysteine rich, a collagen like and a carbohydrate recognition domain. Binding of MBL leads to the activation of MBL-associated serine proteases (MASP's). Activated MASP-2 cleaves C4 and C2 in a similar way as C1s do for the classical pathway (CP) leading to the formation of C4b2a, cleavage of the classical pathway convertase C3, and eventually complement activation up to the formation of the membrane attack complex. MBL is able to activate the complement pathway independent of the classical and alternative complement activation pathways. MBL is predominantly synthesized by hepatocytes and has been isolated from the liver or serum of several vertebrate species. Only one form of human MBL has been characterized, while two forms are found in rhesus monkeys, rabbits, rats and mice. The mouse forms are known as MBL-A and MBL-C. The MBL-C concentrations in serum are about 6-fold compared to that of MBL-A. MBL-A, but not MBL-C, was found to be an acute phase protein in casein and LPS-injection models. MBL-C exists in higher oligomeric forms than MBL-A.Synonyms: MBL, MBL2, MBP, MBP-C, MBP1, Mannan-binding protein, Mannose-binding lectin, Mannose-binding protein C

ID gène: 17195

NCBI Accession: NP_034906

UniProt: P41317