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MTDH anticorps

MTDH Reactivité: Humain WB, IHC (p), EIA Hôte: Souris Monoclonal 2F11C3 unconjugated
N° du produit ABIN1108306
  • Antigène Voir toutes MTDH Anticorps
    MTDH (Metadherin (MTDH))
    Reactivité
    • 49
    • 18
    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 41
    • 6
    • 3
    Souris
    Clonalité
    • 46
    • 4
    Monoclonal
    Conjugué
    • 28
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp MTDH est non-conjugé
    Application
    • 40
    • 15
    • 13
    • 13
    • 11
    • 10
    • 8
    • 8
    • 7
    • 4
    • 3
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificité
    This antibody reacts to Metadherin.
    Réactivité croisée (Details)
    Species reactivity (tested):Human.
    Purification
    Affinity chromatography on Protein G
    Clone
    2F11C3
    Isotype
    IgG1
    Top Product
    Discover our top product MTDH Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS, 0,03 % sodium azide, 50 % glycerol
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Antigène
    MTDH (Metadherin (MTDH))
    Autre désignation
    MTDH (MTDH Produits)
    Synonymes
    anticorps MGC75963, anticorps 2610103J23Rik, anticorps 3D3, anticorps 3D3/Lyric, anticorps AEG-1, anticorps AV353288, anticorps D8Bwg1112e, anticorps Lyric, anticorps AEG1, anticorps LYRIC, anticorps LYRIC/3D3, anticorps metadherin, anticorps mtdh, anticorps MTDH, anticorps Mtdh
    Sujet
    Metadherin (Metastasis adhesion protein), also known as MTDH, LYsine-RIch CEACAM1 co-isolated (LYRIC), is a novel protein that localizes with the tight junction proteins ZO-1 and occludin in polarized epithelial cells. At the tight junction, it acts not as a structural component, but is rather recruited during the maturation of the tight junction complex. Metadherin is overexpressed in breast cancer tissue and breast tumor xenografts, while much lower levels are expressed in normal breast tissue. Metadherin binds to lung vasculature, one of the four common sites of breast cancer metastasis, through a C-terminal segment in the extracellular domain, blocking this lung-homing domain with antibodies or inhibiting metadherin with siRNA has been reported to inhibit breast cancer metastasis.Synonyms: 3D3/LYRIC, AEG-1, AEG1, Astrocyte elevated gene-1 protein, LYRIC, Lysine-rich CEACAM1 co-isolated protein, Metadherin, Metastasis adhesion protein
    Poids moléculaire
    64 kDa
    ID gène
    92140
    Pathways
    Cellular Response to Molecule of Bacterial Origin, Cell-Cell Junction Organization
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