PAI1 anticorps
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- Antigène Voir toutes PAI1 (SERPINE1) Anticorps
- PAI1 (SERPINE1) (Plasminogen Activator Inhibitor 1 (SERPINE1))
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Reactivité
- Humain, Souris, Rat
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp PAI1 est non-conjugé
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Application
- Western Blotting (WB), Enzyme Immunoassay (EIA), Functional Studies (Func)
- Specificité
- This antibody detects PAI-1. The epitope of the antibody does not cover the complete alpha-helix F and turn connecting alpha-helix F and beta-strand s3A, but is restricted to the hinge region between alpha-helix F and the main part of the PAI-1 Molecule. The monoclonal antibody MA-33H1F7 is a 'switching' antibody, capable of inducing a non-inhibitory substrate form of PAI-1. It was shown to inhibit PAI-1 in a dose dependent manner.
- Réactivité croisée (Details)
- Species reactivity (tested):Human, rat, mouse
- Purification
- Protein G
- Clone
- MA-33H1F7
- Isotype
- IgG1
- Top Product
- Discover our top product SERPINE1 Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 0.1 mg/mL
- Buffer
- PBS, 0.1 % bovine serum albumin
- Stock
- 4 °C
- Stockage commentaire
- Store at 2 - 8 °C.
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- Antigène
- PAI1 (SERPINE1) (Plasminogen Activator Inhibitor 1 (SERPINE1))
- Autre désignation
- SERPINE1 / PAI1 (SERPINE1 Produits)
- Synonymes
- anticorps PAI, anticorps PAI-1, anticorps PAI1, anticorps PLANH1, anticorps SERPINE1, anticorps si:ch211-138a11.1, anticorps Planh1, anticorps PAI1A, anticorps Pai1, anticorps Pai1aa, anticorps Planh, anticorps RATPAI1A, anticorps serpin family E member 1, anticorps serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 L homeolog, anticorps serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1, anticorps serine (or cysteine) peptidase inhibitor, clade E, member 1, anticorps SERPINE1, anticorps serpine1.L, anticorps serpine1, anticorps Serpine1
- Sujet
- Plasminogen activator inhibitor type-1 (PAI-1), a member of the serine protease inhibitor (serpin) superfamily, is an important protein in the regulation of fibrinolysis. PAI-1 is unique among the serpins because of its functional and conformational flexibility. PAI-1 is the most important physiological inhibitor of both tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA). Increased PAI-1 levels are associated with thrombotic events and is an established risk factor for cardiovascular diseases. The active conformation PAI-1 inhibits its target proteinases by the formation of a stable, inactive complex. Although PAI-1 is synthesized as an active molecule, it converts spontaneously to an inactive, latent form that can be partially reactivated by denaturing agents. In addition, a third conformation reacting as a non-inhibitory substrate towards various target proteinases has been identified. The epitope of monoclonal antibody MA-33H1F7 is predominantly composed of three residues (Lys154/Glu130/Arg131), positioned virtually linearly in the three-dimensional structure.Synonyms: Endothelial plasminogen activator inhibitor, PAI, PAI-1, PLANH1, Plasminogen Activator Inhibitor 1, Serpin E1
- ID gène
- 5054
- NCBI Accession
- NP_000593
- UniProt
- P05121
- Pathways
- Signalisation p53, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Autophagy, Smooth Muscle Cell Migration
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