F12 anticorps (Light Chain)

N° du produit ABIN111207

Détail du produit anti-F12 anticorps

Antigène: F12 (Coagulation Factor XII (F12))

Épitope: Light Chain

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp F12 est non-conjugé

Application: Enzyme Immunoassay (EIA), Functional Studies (Func)

Specificité: Reacts with the light chain of human Factor XII and at 100nM inhibits 50 % of Factor XII activity.

Purification: Protein G affinity chromatography

Immunogène: Purified human Factor XII

Clone: 802

Isotype: IgG1

Information d'application

Indications d'application: ELISA, to detect/quantitate Factor XII and in coagulation assays.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.95 mg/mL

Buffer: PBS, pH 7.4, without preservative

Agent conservateur: Without preservative

Conseil sur la manipulation: Aliquot to Avoid multiple freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: Upon receipt, store at -20 °C to -70 °C.

Détails sur F12

Antigène: F12 (Coagulation Factor XII (F12))

Abstract: F12 Produits

Synonymes: anticorps HAE3, anticorps HAEX, anticorps HAF, anticorps FXII, anticorps coagulation factor XII, anticorps coagulation factor XII (Hageman factor), anticorps F12

Sujet: Coagulation factor XII circulates in blood as a zymogen. This single chain zymogen is converted to a two chain serine protease with an heavy chain (alpha factor XIIa) and a light chain. The heavy chain contains two fibronectin type domains, two epidermal growth factor (EGF) like domains, a kringle domain and a proline rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta factor XIIa light chain and the alpha factor XIIa light chain becomes beta factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha factor XIIa and then to beta factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in Factor XII gene do not cause any clinical symptoms and the sole effect is that whole blood clotting time is prolonged.Synonyms: HAF, Hageman factor

ID gène: 2161

NCBI Accession: NP_000496

UniProt: P00748

Pathways: Système du Complément