CDK4 anticorps
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- Antigène Voir toutes CDK4 Anticorps
- CDK4 (Cyclin-Dependent Kinase 4 (CDK4))
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Reactivité
- Humain, Souris, Rat, Porc
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp CDK4 est non-conjugé
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Application
- Western Blotting (WB), Immunoprecipitation (IP)
- Specificité
- This antibody reacts specifically with cdk4 protein present predominantly in G1 phase of cell cycle, it does not cross-react with cyclins. Especially suitable for immunoprecipitation, mab DCS-35 precipitates the cdk4/cyclin complex.
- Purification
- Protein A affinity chromatography
- Immunogène
- Human recombinant full-length cdk4 polypeptide
- Clone
- DCS-35
- Isotype
- IgG1
- Top Product
- Discover our top product CDK4 Anticorps primaire
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- Indications d'application
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Immunoprecipitation: 1: 3 - 1: 10, 1 - 4 h at RT or overnight at 2-8C. Western Blot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Reconstitution
- Restore in 1 mL dist. water
- Buffer
- PBS buffer, pH 7.4 containing 0.09 % NaN3, 0.5 % BSA
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Antigène
- CDK4 (Cyclin-Dependent Kinase 4 (CDK4))
- Autre désignation
- CDK4 (CDK4 Produits)
- Synonymes
- anticorps zgc:153726, anticorps CMM3, anticorps PSK-J3, anticorps Crk3, anticorps 8-6, anticorps CDK4, anticorps CDK4/6, anticorps CG5072, anticorps Cdk4/6, anticorps DmCdk4, anticorps Dmel\\CG5072, anticorps Pk53C, anticorps Pk?7, anticorps cdk, anticorps cdk4, anticorps cdk4/6, anticorps dCdk4, anticorps l(2)05428, anticorps l(2)0671, anticorps l(2)k06503, anticorps l(2)s4639, anticorps l(2)sh0671, anticorps xcdk4, anticorps cyclin-dependent kinase 4, anticorps cyclin dependent kinase 4, anticorps Cyclin-dependent kinase 4, anticorps cyclin-dependent kinase 4 L homeolog, anticorps cdk4, anticorps CDK4, anticorps Cdk4, anticorps cdk4.L
- Sujet
- Cdk4 is a member of the Ser/Thr protein kinase family. It is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. Cdk4 is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1/S phase, which is controlled by the regulatory subunits D type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). The mutations in this gene as well as its related proteins including D type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Two alternatively spliced variants, and multiple polyadenylation sites of this gene have been reported.Synonyms: Cell division protein kinase 4, Cyclin-dependent kinase 4, PSK-J3
- ID gène
- 1019
- NCBI Accession
- NP_000066
- UniProt
- P11802
- Pathways
- Cycle Cellulaire, Mitotic G1-G1/S Phases, Regulation of Cell Size
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