Yoon, Yoshida, Johnson, Takikawa, Usui, Tobe, Nakagawa, Yoshino, Imai: "SIRT1-Mediated eNAMPT Secretion from Adipose Tissue Regulates Hypothalamic NAD+ and Function in Mice." dans: Cell metabolism, Vol. 21, Issue 5, pp. 706-17, (2015) (PubMed).
Kover, Tong, Watkins, Clements, Stehno-Bittel, Novikova, Bittel, Kibiryeva, Stuhlsatz, Yan, Ye, Moore: "Expression and regulation of nampt in human islets." dans: PLoS ONE, Vol. 8, Issue 3, pp. e58767, (2013) (PubMed).
Garten, Petzold, Barnikol-Oettler, Körner, Thasler, Kratzsch, Kiess, Gebhardt: "Nicotinamide phosphoribosyltransferase (NAMPT/PBEF/visfatin) is constitutively released from human hepatocytes." dans: Biochemical and biophysical research communications, Vol. 391, Issue 1, pp. 376-81, (2010) (PubMed).
Körner, Garten, Blüher, Tauscher, Kratzsch, Kiess: "Molecular characteristics of serum visfatin and differential detection by immunoassays." dans: The Journal of clinical endocrinology and metabolism, Vol. 92, Issue 12, pp. 4783-91, (2007) (PubMed).
Revollo, Körner, Mills, Satoh, Wang, Garten, Dasgupta, Sasaki, Wolberger, Townsend, Milbrandt, Kiess, Imai: "Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme." dans: Cell metabolism, Vol. 6, Issue 5, pp. 363-75, (2007) (PubMed).
Bae, Kim, Kim, Kim, Koo, Jang, Yun, Yoo, Bae: "Hypoxic induction of human visfatin gene is directly mediated by hypoxia-inducible factor-1." dans: FEBS letters, Vol. 580, Issue 17, pp. 4105-13, (2006) (PubMed).
Nicotinamide phosphoribosyltransferase (Nampt, pre-B cell colony-enhancing factor, PBEF, Visfatin) is an 52 kDa adipokine secreted by adipose tissue and involved in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). Two forms of Nampt exist, an intracellular form (iNampt) and an extracellular form (eNampt). While the function of iNampt as an essential and rate-limiting NAD+ biosynthetic enzyme is well established, the physiological role of eNampt is still a matter of debate. Nampt has various functions, including the promotion of vascular smooth muscle cell maturation and inhibition of neutrophil apoptosis. It activates insulin receptor and has insulin-mimetic effects, lowering blood glucose and improving insulin sensitivity. The protein is highly expressed in visceral fat and serum levels of the protein correlate with obesity.