NLRP6 anticorps

N° du produit ABIN1169061

Détail du produit anti-NLRP6 anticorps

Antigène: NLRP6 (NLR Family, Pyrin Domain Containing 6 (NLRP6))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NLRP6 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificité: Recognizes human NLRP6.

Réactivité croisée: Humain

Purification: Purified from concentrated hybridoma tissue culture supernatant.

Pureté: >95 % (SDS-PAGE)

Immunogène: Recombinant human NLRP6 (NACHT domain).

Clone: Clint-1

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Date de péremption: 12 months

Détails sur NLRP6

Antigène: NLRP6 (NLR Family, Pyrin Domain Containing 6 (NLRP6))

Autre désignation: NLRP6/NALP6 (NLRP6 Produits)

Synonymes: anticorps NLRP6, anticorps NALP6, anticorps AVR, anticorps CLR11.4, anticorps NAVR, anticorps NAVR/AVR, anticorps PAN3, anticorps PYPAF5, anticorps AI504961, anticorps Avr, anticorps Nalp6, anticorps Navr, anticorps Navr/Avr, anticorps Pypaf5, anticorps NLR family pyrin domain containing 6, anticorps NLR family, pyrin domain containing 6, anticorps NLRP6, anticorps Nlrp6

Sujet: The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor (NLR) family are critical components of the inflammasome that link danger-signals to caspase-1 activation. NLRP6/NALP6 is important for intestinal homeostasis by sensing pathogenic commensal bacteria and activating bactericidal activity of macrophages through secretion of IL-18. NLRP6 suppresses inflammation and carcinogenesis by regulating tissue repair and deletion of NLRP6 gene accelerated colitis-associated tumor growth in mice.

UniProt: P59044

Pathways: Inflammasome