STS anticorps (N-Term)

N° du produit ABIN1169071

Détail du produit anti-STS anticorps

Antigène: STS (Steroid Sulfatase (STS))

Épitope: N-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp STS est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP), Functional Studies (Func)

Specificité: Recognizes human and mouse Asc.

Réactivité croisée: Humain, Souris

Immunogène: Synthetic peptide corresponding to aa at the N-terminal human Asc.

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Date de péremption: 12 months

Références pour anticorps anti-STS (ABIN1169071)

Cao, Tian, Li, Lv, Han, Zhuang, Cheng, Gong, Ying, Jin, Gao: "Suppression of NLRP3 Inflammasome by Erythropoietin via the EPOR/JAK2/STAT3 Pathway Contributes to Attenuation of Acute Lung Injury in Mice." dans: Frontiers in pharmacology, Vol. 11, pp. 306, (2020) (PubMed).

Chen, Jiang, Liu, Li, Pei, Wang, Pan, Cui, Long, Wang, Zheng: "Melatonin alleviates intervertebral disc degeneration by disrupting the IL-1β/NF-κB-NLRP3 inflammasome positive feedback loop." dans: Bone research, Vol. 8, pp. 10, (2020) (PubMed).

Liu, Lu, Chen, Muthuraj, Li, Pattabiraman, Zempleni, Kachman, Natarajan, Yu: "Protective Role of Shiitake Mushroom-Derived Exosome-Like Nanoparticles in D-Galactosamine and Lipopolysaccharide-Induced Acute Liver Injury in Mice." dans: Nutrients, Vol. 12, Issue 2, (2020) (PubMed).

Rudloff, Ung, Dowling, Mansell, DAndrea, Ellisdon, Whisstock, Berger, Nold-Petry, Nold: "Parsing the IL-37-Mediated Suppression of Inflammasome Function." dans: Cells, Vol. 9, Issue 1, (2020) (PubMed).

Deng, Guo, Tam, Johnson, Brickey, New, Lenox, Shi, Golenbock, Koller, McKinnon, Beutler, Ting: "Platelet-activating factor (PAF) mediates NLRP3-NEK7 inflammasome induction independently of PAFR." dans: The Journal of experimental medicine, Vol. 216, Issue 12, pp. 2838-2853, (2020) (PubMed).

Sanchez-Lopez, Zhong, Stubelius, Sweeney, Booshehri, Antonucci, Liu-Bryan, Lodi, Terkeltaub, Lacal, Murphy, Hoffman, Tiziani, Guma, Karin: "Choline Uptake and Metabolism Modulate Macrophage IL-1β and IL-18 Production." dans: Cell metabolism, Vol. 29, Issue 6, pp. 1350-1362.e7, (2020) (PubMed).

Guo, Liu, Jian, Cui, Fang, Zuo, Deng, Li, Wang, Zhao, Geng, Ouyang, Lai, Chen, Huang: "Nickel induces inflammatory activation via NF-κB, MAPKs, IRF3 and NLRP3 inflammasome signaling pathways in macrophages." dans: Aging, Vol. 11, Issue 23, pp. 11659-11672, (2019) (PubMed).

Martínez-García, Martínez-Banaclocha, Angosto-Bazarra, de Torre-Minguela, Baroja-Mazo, Alarcón-Vila, Martínez-Alarcón, Amores-Iniesta, Martín-Sánchez, Ercole, Martínez, González-Lisorge et al.: "P2X7 receptor induces mitochondrial failure in monocytes and compromises NLRP3 inflammasome activation during sepsis. ..." dans: Nature communications, Vol. 10, Issue 1, pp. 2711, (2019) (PubMed).

Panaitescu, Romero, Gomez-Lopez, Xu, Leng, Maymon, Pacora, Erez, Yeo, Hassan, Hsu: "In vivo evidence of inflammasome activation during spontaneous labor at term." dans: The journal of maternal-fetal & neonatal medicine, Vol. 32, Issue 12, pp. 1978-1991, (2019) (PubMed).

Wang, Gong, Zhang, Li, Lu, Zhao, Yu, Wei, Yang, Liu, Yang, Li, Zhang: "NLRP3 Inflammasome Participates in Host Response to Neospora caninum Infection." dans: Frontiers in immunology, Vol. 9, pp. 1791, (2019) (PubMed).

Zhong, Liang, Sanchez-Lopez, He, Shalapour, Lin, Wong, Ding, Seki, Schnabl, Hevener, Greenberg, Kisseleva, Karin: "New mitochondrial DNA synthesis enables NLRP3 inflammasome activation." dans: Nature, Vol. 560, Issue 7717, pp. 198-203, (2019) (PubMed).

Gomez-Lopez, Romero, Xu, Garcia-Flores, Leng, Panaitescu, Miller, Abrahams, Hassan: "Inflammasome assembly in the chorioamniotic membranes during spontaneous labor at term." dans: American journal of reproductive immunology (New York, N.Y. : 1989), Vol. 77, Issue 5, (2018) (PubMed).

Gomez-Lopez, Romero, Panaitescu, Leng, Xu, Tarca, Faro, Pacora, Hassan, Hsu: "Inflammasome activation during spontaneous preterm labor with intra-amniotic infection or sterile intra-amniotic inflammation." dans: American journal of reproductive immunology (New York, N.Y. : 1989), Vol. 80, Issue 5, pp. e13049, (2018) (PubMed).

Lugrin, Martinon: "Detection of ASC Oligomerization by Western Blotting." dans: Bio-protocol, Vol. 7, Issue 10, (2017) (PubMed).

Dang, McDonald, Russell, Cyster: "Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation." dans: Cell, Vol. 171, Issue 5, pp. 1057-1071.e11, (2017) (PubMed).

Fernández-Gil, Moneim, Ortiz, Shen, Soto-Mercado, Mendivil-Perez, Guerra-Librero, Acuña-Castroviejo, Molina-Navarro, García-Verdugo, Sayed, Florido, Luna, López, Escames: "Melatonin protects rats from radiotherapy-induced small intestine toxicity." dans: PLoS ONE, Vol. 12, Issue 4, pp. e0174474, (2017) (PubMed).

Man, Karki, Sasai, Place, Kesavardhana, Temirov, Frase, Zhu, Malireddi, Kuriakose, Peters, Neale, Brown, Yamamoto, Kanneganti: "IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes." dans: Cell, Vol. 167, Issue 2, pp. 382-396.e17, (2017) (PubMed).

Tervaniemi, Katayama, Skoog, Siitonen, Vuola, Nuutila, Sormunen, Johnsson, Linnarsson, Suomela, Kankuri, Kere, Elomaa: "NOD-like receptor signaling and inflammasome-related pathways are highlighted in psoriatic epidermis." dans: Scientific reports, Vol. 6, pp. 22745, (2016) (PubMed).

Man, Karki, Malireddi, Neale, Vogel, Yamamoto, Lamkanfi, Kanneganti: "The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection." dans: Nature immunology, Vol. 16, Issue 5, pp. 467-75, (2015) (PubMed).

Ortiz, Acuña-Castroviejo, Doerrier, Dayoub, López, Venegas, García, López, Volt, Luna-Sánchez, Escames: "Melatonin blunts the mitochondrial/NLRP3 connection and protects against radiation-induced oral mucositis." dans: Journal of pineal research, (2014) (PubMed).

Détails sur STS

Antigène: STS (Steroid Sulfatase (STS))

Autre désignation: Asc (STS Produits)

Synonymes: anticorps 9130417A21Rik, anticorps Asc, anticorps CARD5, anticorps TMS-1, anticorps TNS1, anticorps masc, anticorps ARSC, anticorps ARSC1, anticorps ASC, anticorps ES, anticorps SSDD, anticorps XLI, anticorps PYD and CARD domain containing, anticorps steroid sulfatase, anticorps Pycard, anticorps STS, anticorps Sts

Sujet: Asc promotes caspase-mediated apoptosis. This proapoptotic activity is mediated predominantly through the activation of caspase-9. It is a component of the inflammasome, a protein complex which also includes NLRP3/NALP3, CARD8 and CASP1 and whose function is the activation of proinflammatory caspases.

UniProt: Q9ULZ3

Pathways: Steroid Hormone Biosynthesis, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Activated T Cell Proliferation