IDO1 anticorps

N° du produit ABIN1169195

Détail du produit anti-IDO1 anticorps

Antigène: IDO1 (Indoleamine 2,3-Dioxygenase 1 (IDO1))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IDO1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Specificité: Recognizes mouse IDO. Detects a band of ~45 kDa by Western blot.

Réactivité croisée: Souris

Stérilité: 0.2 μm filtered

Immunogène: Recombinant mouse IDO.

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives.

Agent conservateur: Without preservative

Stock: 4 °C,-20 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C.

Date de péremption: 6 months

Références pour anticorps anti-IDO1 (ABIN1169195)

Jung, Lee, Chang, Lee, Jeong, Lee, Park, Han, Seo, Lee, Park: "Blockade of indoleamine 2,3-dioxygenase protects mice against lipopolysaccharide-induced endotoxin shock." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 5, pp. 3146-54, (2009) (PubMed).

Yen, Lin, Chen, Huang, Yang, Chang, Lei, Lai: "A novel cancer therapy by skin delivery of indoleamine 2,3-dioxygenase siRNA." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 15, Issue 2, pp. 641-9, (2009) (PubMed).

Cook, Bickerstaff, Wang, Nadasdy, Della Pelle, Colvin, Orosz: "Spontaneous renal allograft acceptance associated with "regulatory" dendritic cells and IDO." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 180, Issue 5, pp. 3103-12, (2008) (PubMed).

Yadav, Burudi, Alirezaei, Flynn, Watry, Lanigan, Fox: "IFN-gamma-induced IDO and WRS expression in microglia is differentially regulated by IL-4." dans: Glia, Vol. 55, Issue 13, pp. 1385-96, (2007) (PubMed).

Détails sur IDO1

Antigène: IDO1 (Indoleamine 2,3-Dioxygenase 1 (IDO1))

Autre désignation: IDO (IDO1 Produits)

Synonymes: anticorps INDO, anticorps ido, anticorps indo, anticorps IDO, anticorps cd107b, anticorps IDO1, anticorps IDO-1, anticorps Ido, anticorps Indo, anticorps indoleamine 2,3-dioxygenase 1, anticorps indoleamine 2,3-dioxygenase 1 L homeolog, anticorps indoleamine 2,3-dioxygenase 1-like, anticorps IDO1, anticorps ido1.L, anticorps ido1, anticorps Ido1, anticorps LOC100050681

Sujet: IDO catalyzes the first and rate-limiting step in the main pathway of human tryptophan catabolism, the kynurenine pathway. Proinflammatory mediators, such as endotoxin and IFN-gamma induce the expression of IDO in several tissues. IDO-dependent suppression of T-cell responses might function as natural immunoregulatory mechanism. Physiological IDO activity has been implicated in T-cell tolerance to tumors, dysfunctional selftolerance in non-obese diabetic (NOD) mice, and as a protective negative regulator in autoimmune disorders.

UniProt: P28776

Pathways: Activated T Cell Proliferation