TNFRSF10A anticorps
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- Antigène Voir toutes TNFRSF10A Anticorps
- TNFRSF10A (Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp TNFRSF10A est non-conjugé
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Application
- Flow Cytometry (FACS), Immunohistochemistry (IHC)
- Specificité
- Recognizes human TRAIL-R1.
- Réactivité croisée
- Humain
- Réactivité croisée (Details)
- Does not cross-react with human TRAIL-R2, -R3 or -R4.
- Purification
- Purified from concentrated hybridoma tissue culture supernatant.
- Pureté
- >95 % (SDS-PAGE)
- Immunogène
- Recombinant human TRAIL-R1 (DR4).
- Clone
- TR1-02
- Isotype
- IgG2b
- Top Product
- Discover our top product TNFRSF10A Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Commentaires
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Specially developed for the immunohistochemical detection of TRAIL-R1 in paraffin embedded tissue. Has been shown to detect TRAIL-R1 expressed at endogenous levels in paraffin-embedded tissue in different mammary carcinoma tissues.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- In PBS containing 10 % glycerol and 0.02 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C. - Date de péremption
- 12 months
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- Antigène
- TNFRSF10A (Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A))
- Autre désignation
- TRAIL-R1 (TNFRSF10A Produits)
- Synonymes
- anticorps APO2, anticorps CD261, anticorps DR4, anticorps TRAILR-1, anticorps TRAILR1, anticorps TNFRSF10A, anticorps TNF receptor superfamily member 10a, anticorps tumor necrosis factor receptor superfamily member 26, anticorps tumor necrosis factor receptor superfamily, member 10a, anticorps TNFRSF10A, anticorps LOC510798
- Sujet
- TRAIL-R1 is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB.
- UniProt
- O00220
- Pathways
- Apoptose, Positive Regulation of Endopeptidase Activity
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