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PIDD anticorps (AA 776-910)

PIDD Reactivité: Humain, Souris IHC, WB, IP Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN1169268
  • Antigène Voir toutes PIDD Anticorps
    PIDD (P53-Induced Death Domain Protein (PIDD))
    Épitope
    • 15
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 776-910
    Reactivité
    • 20
    • 19
    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain, Souris
    Hôte
    • 33
    • 3
    Lapin
    Clonalité
    • 33
    • 3
    Polyclonal
    Conjugué
    • 15
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp PIDD est non-conjugé
    Application
    • 13
    • 13
    • 13
    • 6
    • 6
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Western Blotting (WB), Immunoprecipitation (IP)
    Specificité
    Recognizes human and the native form of mouse PIDD. Detects bands of ~90 kDa (full length protein) and ~50 kDa (cleaved protein) by Western blot.
     Réactivité croisée
    Humain, Souris
    Immunogène
    Recombinant human PIDD (Death Domain: aa 776-910).
    Top Product
    Discover our top product PIDD Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    In PBS containing 10 % glycerol and 0.02 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 1 year after receipt when stored at -20°C.
    Date de péremption
    12 months
  • Milleron, Bratton: "Heat shock induces apoptosis independently of any known initiator caspase-activating complex." dans: The Journal of biological chemistry, Vol. 281, Issue 25, pp. 16991-7000, (2006) (PubMed).

    Janssens, Tinel, Lippens, Tschopp: "PIDD mediates NF-kappaB activation in response to DNA damage." dans: Cell, Vol. 123, Issue 6, pp. 1079-92, (2005) (PubMed).

    Tinel, Tschopp: "The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress." dans: Science (New York, N.Y.), Vol. 304, Issue 5672, pp. 843-6, (2004) (PubMed).

  • Antigène
    PIDD (P53-Induced Death Domain Protein (PIDD))
    Autre désignation
    PIDD (PIDD Produits)
    Synonymes
    anticorps 1200011D09Rik, anticorps AU042446, anticorps Pidd, anticorps LRDD, anticorps Lrdd, anticorps p53 induced death domain protein 1, anticorps p53-induced death domain protein 1, anticorps Pidd1, anticorps PIDD1
    Sujet
    PIDD promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. It associates with NEMO/IKBKG and RIP1 and enhances sumoylation and ubiquitination of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B. It associates with caspase-2 and RAIDD, and induces activation of caspase-2 which is an important regulator in the apoptotic pathways.
    UniProt
    Q9HB75
    Pathways
    Signalisation p53, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity
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