PIDD anticorps (AA 776-910)

N° du produit ABIN1169268

Détail du produit anti-PIDD anticorps

Antigène: PIDD (P53-Induced Death Domain Protein (PIDD))

Épitope: AA 776-910

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PIDD est non-conjugé

Application: Immunohistochemistry (IHC), Western Blotting (WB), Immunoprecipitation (IP)

Specificité: Recognizes human and the native form of mouse PIDD. Detects bands of ~90 kDa (full length protein) and ~50 kDa (cleaved protein) by Western blot.

Réactivité croisée: Humain, Souris

Immunogène: Recombinant human PIDD (Death Domain: aa 776-910).

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Date de péremption: 12 months

Références pour anticorps anti-PIDD (ABIN1169268)

Milleron, Bratton: "Heat shock induces apoptosis independently of any known initiator caspase-activating complex." dans: The Journal of biological chemistry, Vol. 281, Issue 25, pp. 16991-7000, (2006) (PubMed).

Janssens, Tinel, Lippens, Tschopp: "PIDD mediates NF-kappaB activation in response to DNA damage." dans: Cell, Vol. 123, Issue 6, pp. 1079-92, (2005) (PubMed).

Tinel, Tschopp: "The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress." dans: Science (New York, N.Y.), Vol. 304, Issue 5672, pp. 843-6, (2004) (PubMed).

Détails sur PIDD

Antigène: PIDD (P53-Induced Death Domain Protein (PIDD))

Autre désignation: PIDD (PIDD Produits)

Synonymes: anticorps 1200011D09Rik, anticorps AU042446, anticorps Pidd, anticorps LRDD, anticorps Lrdd, anticorps p53 induced death domain protein 1, anticorps p53-induced death domain protein 1, anticorps Pidd1, anticorps PIDD1

Sujet: PIDD promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. It associates with NEMO/IKBKG and RIP1 and enhances sumoylation and ubiquitination of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B. It associates with caspase-2 and RAIDD, and induces activation of caspase-2 which is an important regulator in the apoptotic pathways.

UniProt: Q9HB75

Pathways: Signalisation p53, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity