ANGPTL4 anticorps

N° du produit ABIN1169313

Détail du produit anti-ANGPTL4 anticorps

Antigène: ANGPTL4 (Angiopoietin-Like 4 (ANGPTL4))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ANGPTL4 est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: Recognizes human ANGPTL4. Detects a band of ~35 kDa and 62 kDa by Western blot.

Réactivité croisée: Humain

Stérilité: 0.2 μm filtered

Immunogène: Recombinant human ANGPTL4.

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives.

Agent conservateur: Without preservative

Stock: 4 °C,-20 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C.

Date de péremption: 6 months

Références pour anticorps anti-ANGPTL4 (ABIN1169313)

Broxmeyer, Srour, Cooper, Wallace, Hangoc, Youn: "Angiopoietin-like-2 and -3 act through their coiled-coil domains to enhance survival and replating capacity of human cord blood hematopoietic progenitors." dans: Blood cells, molecules & diseases, Vol. 48, Issue 1, pp. 25-9, (2012) (PubMed).

Détails sur ANGPTL4

Antigène: ANGPTL4 (Angiopoietin-Like 4 (ANGPTL4))

Autre désignation: ANGPTL4 (ANGPTL4 Produits)

Synonymes: anticorps ANGPTL2, anticorps ARP4, anticorps FIAF, anticorps HFARP, anticorps NL2, anticorps PGAR, anticorps pp1158, anticorps Arp4, anticorps Bk89, anticorps Fiaf, anticorps Hfarp, anticorps Ng27, anticorps Pgar, anticorps Pgarg, anticorps Pp1158, anticorps ANGPTL4, anticorps fiaf, anticorps im:7144703, anticorps si:rp71-39b20.7, anticorps angiopoietin like 4, anticorps angiopoietin-like 4, anticorps ANGPTL4, anticorps Angptl4, anticorps angptl4

Sujet: ANGPTL4 mainly expressed in endothelial cells (hypoxia-induced). Regulates angiogenesis and modulates tumorgenesis and directly regulates lipid, glucose, and energy metabolism. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. ANGPTL4 is a protein consisting of an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain (FLD). Both domains have distinct biological functions. The coiled-coil domain is responsible for the inhibitory effects on lipoprotein lipase (LPL) converting the active form of LPL into an inactive form, and the FLD domain mediates its antiangiogenic functions. The coiled coil and the FLD domains are separated by a short linker that can be cleaved after secretion. ANGPTL4 appears on the cell surface as the full-length form, where it can be released by heparin treatment. ANGPTL4 protein is then proteolytically cleaved by proprotein convertases (PCs), including furin, PC5/6, paired basic amino acid-cleaving enzyme 4, and PC7.

UniProt: Q9BY76

Pathways: Regulation of Lipid Metabolism by PPARalpha