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DDX58 anticorps (AA 201-713)

DDX58 Reactivité: Humain, Souris WB, IHC, IP Hôte: Souris Monoclonal Alme-1 unconjugated
N° du produit ABIN1169336
  • Antigène Voir toutes DDX58 Anticorps
    DDX58 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58))
    Épitope
    • 15
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 201-713
    Reactivité
    • 70
    • 41
    • 17
    • 2
    • 1
    Humain, Souris
    Hôte
    • 65
    • 8
    • 1
    • 1
    Souris
    Clonalité
    • 67
    • 8
    Monoclonal
    Conjugué
    • 36
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp DDX58 est non-conjugé
    Application
    • 59
    • 19
    • 14
    • 14
    • 12
    • 11
    • 7
    • 6
    • 4
    • 4
    • 3
    • 3
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
    Specificité
    Recognizes human and mouse RIG-I.
     Réactivité croisée
    Humain, Souris
    Purification
    Purified from concentrated hybridoma tissue culture supernatant.
    Pureté
    >95 % (SDS-PAGE)
    Immunogène
    Recombinant human RIG-I (aa 201-713).
    Clone
    Alme-1
    Isotype
    IgG1
    Top Product
    Discover our top product DDX58 Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    In PBS containing 10 % glycerol and 0.02 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 1 year after receipt when stored at -20°C.
    Date de péremption
    12 months
  • Kell, Hemann, Turnbull, Gale: "RIG-I-like receptor activation drives type I IFN and antiviral signaling to limit Hantaan orthohantavirus replication." dans: PLoS pathogens, Vol. 16, Issue 4, pp. e1008483, (2020) (PubMed).

    Moriyama, Koshiba, Ichinohe: "Influenza A virus M2 protein triggers mitochondrial DNA-mediated antiviral immune responses." dans: Nature communications, Vol. 10, Issue 1, pp. 4624, (2020) (PubMed).

    Soonthornvacharin, Rodriguez-Frandsen, Zhou, Galvez, Huffmaster, Tripathi, Balasubramaniam, Inoue, de Castro, Moulton, Stein, Sánchez-Aparicio, De Jesus, Nguyen, König, Krogan, García-Sastre, Yoh et al.: "Systems-based analysis of RIG-I-dependent signalling identifies KHSRP as an inhibitor of RIG-I receptor activation. ..." dans: Nature microbiology, Vol. 2, pp. 17022, (2018) (PubMed).

    Harden, Munger: "Human papillomavirus 16 E6 and E7 oncoprotein expression alters microRNA expression in extracellular vesicles." dans: Virology, Vol. 508, pp. 63-69, (2017) (PubMed).

    Pythoud, Rothenberger, Martínez-Sobrido, de la Torre, Kunz: "Lymphocytic Choriomeningitis Virus Differentially Affects the Virus-Induced Type I Interferon Response and Mitochondrial Apoptosis Mediated by RIG-I/MAVS." dans: Journal of virology, Vol. 89, Issue 12, pp. 6240-50, (2015) (PubMed).

    Weber, Gawanbacht, Habjan, Rang, Borner, Schmidt, Veitinger, Jacob, Devignot, Kochs, García-Sastre, Weber: "Incoming RNA virus nucleocapsids containing a 5'-triphosphorylated genome activate RIG-I and antiviral signaling." dans: Cell host & microbe, Vol. 13, Issue 3, pp. 336-46, (2013) (PubMed).

    Gack, Nistal-Villán, Inn, García-Sastre, Jung: "Phosphorylation-mediated negative regulation of RIG-I antiviral activity." dans: Journal of virology, Vol. 84, Issue 7, pp. 3220-9, (2010) (PubMed).

    Rebsamen, Meylan, Curran, Tschopp: "The antiviral adaptor proteins Cardif and Trif are processed and inactivated by caspases." dans: Cell death and differentiation, Vol. 15, Issue 11, pp. 1804-11, (2008) (PubMed).

  • Antigène
    DDX58 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58))
    Autre désignation
    RIG-I (DDX58 Produits)
    Synonymes
    anticorps RIG-I, anticorps RIGI, anticorps RLR-1, anticorps 6430573D20Rik, anticorps C330021E21, anticorps RHIV-1, anticorps RIG-1, anticorps DExD/H-box helicase 58, anticorps DEAD (Asp-Glu-Ala-Asp) box polypeptide 58, anticorps DEXD/H-box helicase 58, anticorps DDX58, anticorps Ddx58
    Sujet
    RIG-I and MDA5 are highly conserved helicases involved in the innate immune response to virus. RIG-I is a member of the DEAD-box RNA helicases and is activated by cytoplasmic dsRNA and 5'-ppp RNA produced during the viral replication. The protein is characterized by a N-terminal region with two caspase recruitment domains (CARD) and a C-terminal region harboring potential ATP-dependent RNA helicase activity. RIG-I recruits the CARD adaptor inducing IFN-beta (Cardif) in a CARD-CARD-dependent manner resulting in NF-kappaB and IRF3 activation.
    UniProt
    O95786
    Pathways
    Activation of Innate immune Response, Hepatitis C
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