IL1RL1 anticorps

N° du produit ABIN1169349

Détail du produit anti-IL1RL1 anticorps

Antigène: IL1RL1 (Interleukin 1 Receptor-Like 1 (IL1RL1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IL1RL1 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Specificité: Recognizes soluble human ST2. Detects a band of ~50 kDa by Western blot and the endogenous ST2 by Flow Cytometry.

Réactivité croisée: Humain

Stérilité: 0.2 μm filtered

Immunogène: Recombinant human soluble ST2.

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: In PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C.

Date de péremption: 6 months

Détails sur IL1RL1

Antigène: IL1RL1 (Interleukin 1 Receptor-Like 1 (IL1RL1))

Autre désignation: ST2 (IL1RL1 Produits)

Synonymes: anticorps DER4, anticorps Fit-1, anticorps Ly84, anticorps ST2L, anticorps St2, anticorps St2-rs1, anticorps T1, anticorps T1/ST2, anticorps FIT-1, anticorps IL33R, anticorps ST2, anticorps ST2V, anticorps FIT1, anticorps interleukin 1 receptor-like 1, anticorps interleukin 1 receptor like 1, anticorps Il1rl1, anticorps IL1RL1

Sujet: ST2 is a member of the Toll/IL-1 receptor family. Two forms of the protein exist, a soluble form known as ST2 and a membrane anchored form known as ST2L. The membrane form is expressed by Th2 cells and bone marrow derived mast cells, whereas the soluble form is expressed by serum-stimulated fibroblasts. It binds IL-33 and is structurally similar to IL-1R1. Type 2 innate lymphoid cells (ILC2), originally referred to as natural helper (NH) cells, are a novel target of IL-33. Lung ILC2s participate in the induction of airway inflammation in influenza virus-infected mice and papain-administrated mice. Soluble ST2 plays a role in protecting ILC2 from IL-33 stimulation and thereby maintaining them in a naive state and might be important for the regulation of several disease. Blocking with anti-ST2 antibodies has been shown to alleviate experimental arthritis and airway inflammation. The IL-33-ST2 axis is is involved across a range of diseases including asthma, allergies, obesity and cardiac disease.

UniProt: Q01638