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Caspase 1 p20 anticorps

Reactivité: Humain WB Hôte: Souris Monoclonal Bally-1 unconjugated
N° du produit ABIN1169380
  • Antigène Tous les produits Caspase 1 p20
    Caspase 1 p20
    Reactivité
    • 50
    • 34
    • 32
    Humain
    Hôte
    • 49
    • 3
    Souris
    Clonalité
    • 49
    • 3
    Monoclonal
    Conjugué
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    Cet anticorp Caspase 1 p20 est non-conjugé
    Application
    • 42
    • 36
    • 26
    • 26
    • 10
    • 9
    • 6
    • 2
    • 2
    • 2
    Western Blotting (WB)
    Specificité
    Recognizes endogenous full-length and activated (p20 fragment) human caspase-1.
     Réactivité croisée
    Humain
    Purification
    Purified from concentrated hybridoma tissue culture supernatant.
    Pureté
    >95 % (SDS-PAGE)
    Immunogène
    Recombinant human caspase-1.
    Clone
    Bally-1
    Isotype
    IgG1
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    In PBS containing 10 % glycerol and 0.02 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 1 year after receipt when stored at -20°C.
    Date de péremption
    12 months
  • Rolfes, Ribeiro, Hawwari, Böttcher, Rosero, Maasewerd, Santos, Próchnicki, Silva, Wanderley, Rothe, Schmidt, Stunden, Bertheloot, Rivas, Fontes, Carvalho, Cunha, Latz, Arditi, Franklin: "Platelets Fuel the Inflammasome Activation of Innate Immune Cells." dans: Cell reports, Vol. 31, Issue 6, pp. 107615, (2020) (PubMed).

    Hamarsheh, Osswald, Saller, Unger, De Feo, Vinnakota, Konantz, Uhl, Becker, Lübbert, Shoumariyeh, Schürch, Andrieux, Venhoff, Schmitt-Graeff, Duquesne, Pfeifer, Cooper, Lengerke, Boerries, Duyster et al.: "Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation. ..." dans: Nature communications, Vol. 11, Issue 1, pp. 1659, (2020) (PubMed).

    Xue, Xi, Liu, Guo, Zhang, Zhang, Li, Yang, Zhou, Yang, Zhang, Zhang, Gu, Yang, Da, Yao, Duo, Zhang: "miR-21 promotes NLRP3 inflammasome activation to mediate pyroptosis and endotoxic shock." dans: Cell death & disease, Vol. 10, Issue 6, pp. 461, (2020) (PubMed).

    Wu, Lu, Zhang, Zhang, Shi, Hisada, Grover, Zhang, Li, Xiang, Shi, Li, Daugherty, Smyth, Kirchhofer, Shiroishi, Shao, Mackman, Wei, Li: "Inflammasome Activation Triggers Blood Clotting and Host Death through Pyroptosis." dans: Immunity, Vol. 50, Issue 6, pp. 1401-1411.e4, (2019) (PubMed).

    Mehto, Jena, Nath, Chauhan, Kolapalli, Das, Sahoo, Jain, Taylor, Chauhan: "The Crohn's Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy." dans: Molecular cell, Vol. 73, Issue 3, pp. 429-445.e7, (2019) (PubMed).

    Honda, Sadatomi, Yamamura, Nakashioya, Tanimura, Takeda: "WP1066 suppresses macrophage cell death induced by inflammasome agonists independently of its inhibitory effect on STAT3." dans: Cancer science, Vol. 108, Issue 3, pp. 520-527, (2017) (PubMed).

    Gaidt, Ebert, Chauhan, Ramshorn, Pinci, Zuber, ODuill, Schmid-Burgk, Hoss, Buhmann, Wittmann, Latz, Subklewe, Hornung: "The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3." dans: Cell, Vol. 171, Issue 5, pp. 1110-1124.e18, (2017) (PubMed).

    Derangère, Chevriaux, Courtaut, Bruchard, Berger, Chalmin, Causse, Limagne, Végran, Ladoire, Simon, Boireau, Hichami, Apetoh, Mignot, Ghiringhelli, Rébé: "Liver X receptor ? activation induces pyroptosis of human and murine colon cancer cells." dans: Cell death and differentiation, Vol. 21, Issue 12, pp. 1914-24, (2014) (PubMed).

  • Antigène
    Caspase 1 p20
    Autre désignation
    Caspase-1 p20 (Caspase 1 p20 Produits)
    Sujet
    Caspase-1 is the best-described inflammatory caspase. It processes the cytokines interleukin-1beta (IL-1beta) and IL-18 and induces pyroptotic cell death. Caspase-1 is activated by multiprotein complexes called Inflammasomes in response to numerous stimuli that are detected through distinct inflammasomes. NLRC4 responds to cytosolic flagellin, murine NLRP1b responds to anthrax lethal toxin, AIM2 responds to cytosolic DNA and NLRP3 responds to a variety of agonists including crystals.
    UniProt
    P29466
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