Caspase 1 p20 anticorps
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- Antigène Tous les produits Caspase 1 p20
- Caspase 1 p20
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp Caspase 1 p20 est non-conjugé
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Application
- Western Blotting (WB)
- Specificité
- Recognizes endogenous full-length and activated (p20 fragment) human caspase-1.
- Réactivité croisée
- Humain
- Purification
- Purified from concentrated hybridoma tissue culture supernatant.
- Pureté
- >95 % (SDS-PAGE)
- Immunogène
- Recombinant human caspase-1.
- Clone
- Bally-1
- Isotype
- IgG1
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- In PBS containing 10 % glycerol and 0.02 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C. - Date de péremption
- 12 months
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Platelets Fuel the Inflammasome Activation of Innate Immune Cells." dans: Cell reports, Vol. 31, Issue 6, pp. 107615, (2020) (PubMed).
: "Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation. ..." dans: Nature communications, Vol. 11, Issue 1, pp. 1659, (2020) (PubMed).
: "miR-21 promotes NLRP3 inflammasome activation to mediate pyroptosis and endotoxic shock." dans: Cell death & disease, Vol. 10, Issue 6, pp. 461, (2020) (PubMed).
: "Inflammasome Activation Triggers Blood Clotting and Host Death through Pyroptosis." dans: Immunity, Vol. 50, Issue 6, pp. 1401-1411.e4, (2019) (PubMed).
: "The Crohn's Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy." dans: Molecular cell, Vol. 73, Issue 3, pp. 429-445.e7, (2019) (PubMed).
: "WP1066 suppresses macrophage cell death induced by inflammasome agonists independently of its inhibitory effect on STAT3." dans: Cancer science, Vol. 108, Issue 3, pp. 520-527, (2017) (PubMed).
: "The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3." dans: Cell, Vol. 171, Issue 5, pp. 1110-1124.e18, (2017) (PubMed).
: "Liver X receptor ? activation induces pyroptosis of human and murine colon cancer cells." dans: Cell death and differentiation, Vol. 21, Issue 12, pp. 1914-24, (2014) (PubMed).
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Platelets Fuel the Inflammasome Activation of Innate Immune Cells." dans: Cell reports, Vol. 31, Issue 6, pp. 107615, (2020) (PubMed).
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- Antigène
- Caspase 1 p20
- Autre désignation
- Caspase-1 p20 (Caspase 1 p20 Produits)
- Sujet
- Caspase-1 is the best-described inflammatory caspase. It processes the cytokines interleukin-1beta (IL-1beta) and IL-18 and induces pyroptotic cell death. Caspase-1 is activated by multiprotein complexes called Inflammasomes in response to numerous stimuli that are detected through distinct inflammasomes. NLRC4 responds to cytosolic flagellin, murine NLRP1b responds to anthrax lethal toxin, AIM2 responds to cytosolic DNA and NLRP3 responds to a variety of agonists including crystals.
- UniProt
- P29466
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