Caspase 1 p20 anticorps

N° du produit ABIN1169381

Détail du produit anti-Caspase 1 p20 anticorps

Antigène: Caspase 1 p20

Reactivité: Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Caspase 1 p20 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)

Specificité: Recognizes endogenous full-length and activated (p20 fragment) mouse caspase-1.

Réactivité croisée: Souris

Purification: Purified from concentrated hybridoma tissue culture supernatant.

Pureté: >95 % (SDS-PAGE)

Immunogène: Recombinant mouse caspase-1.

Clone: Casper-1

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Date de péremption: 12 months

Références pour anticorps anti-Caspase 1 p20 (ABIN1169381)

Yamazaki, Ohshio, Sugamata, Morita: "Lactic acid bacterium, Lactobacillus paracasei KW3110, suppresses inflammatory stress-induced caspase-1 activation by promoting interleukin-10 production in mouse and human immune cells." dans: PLoS ONE, Vol. 15, Issue 8, pp. e0237754, (2020) (PubMed).

Hooftman, Angiari, Hester, Corcoran, Runtsch, Ling, Ruzek, Slivka, McGettrick, Banahan, Hughes, Irvine, Fischer, ONeill: "The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation." dans: Cell metabolism, Vol. 32, Issue 3, pp. 468-478.e7, (2020) (PubMed).

de Vasconcelos, Van Opdenbosch, Van Gorp, Martín-Pérez, Zecchin, Vandenabeele, Lamkanfi: "An Apoptotic Caspase Network Safeguards Cell Death Induction in Pyroptotic Macrophages." dans: Cell reports, Vol. 32, Issue 4, pp. 107959, (2020) (PubMed).

Heilig, Dilucca, Boucher, Chen, Hancz, Demarco, Shkarina, Broz: "Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMD." dans: Life science alliance, Vol. 3, Issue 6, (2020) (PubMed).

Wang, Li, Liu, Peng, Zhu, Tu, Yu, Li: "CircHIPK3 Promotes Pyroptosis in Acinar Cells Through Regulation of the miR-193a-5p/GSDMD Axis." dans: Frontiers in medicine, Vol. 7, pp. 88, (2020) (PubMed).

Donado, Cao, Simmons, Croker, Brennan, Brenner: "A Two-Cell Model for IL-1β Release Mediated by Death-Receptor Signaling." dans: Cell reports, Vol. 31, Issue 1, pp. 107466, (2020) (PubMed).

Place, Briard, Samir, Karki, Bhattacharya, Guy, Peters, Frase, Vogel, Neale, Yamamoto, Kanneganti: "Interferon inducible GBPs restrict Burkholderia thailandensis motility induced cell-cell fusion." dans: PLoS pathogens, Vol. 16, Issue 3, pp. e1008364, (2020) (PubMed).

Subbarao, Sanchez-Garrido, Krishnan, Shenoy, Robertson: "Genetic and pharmacological inhibition of inflammasomes reduces the survival of Mycobacterium tuberculosis strains in macrophages." dans: Scientific reports, Vol. 10, Issue 1, pp. 3709, (2020) (PubMed).

Cohen, Baram, Edry-Botzer, Munitz, Salomon, Gerlic: "Vibrio pore-forming leukocidin activates pyroptotic cell death via the NLRP3 inflammasome." dans: Emerging microbes & infections, Vol. 9, Issue 1, pp. 278-290, (2020) (PubMed).

Wang, Xu, Zhao, Yin, Liu, Chen, Hou: "Arf1-mediated lipid metabolism sustains cancer cells and its ablation induces anti-tumor immune responses in mice." dans: Nature communications, Vol. 11, Issue 1, pp. 220, (2020) (PubMed).

Krause, Daily, Estfanous, Hamilton, Badr, Abu Khweek, Hegazi, Anne, Klamer, Zhang, Gavrilin, Pancholi, Amer: "Caspase-11 counteracts mitochondrial ROS-mediated clearance of Staphylococcus aureus in macrophages." dans: EMBO reports, Vol. 20, Issue 12, pp. e48109, (2020) (PubMed).

de Vasconcelos, Vliegen, Gonçalves, De Hert, Martín-Pérez, Van Opdenbosch, Jallapally, Geiss-Friedlander, Lambeir, Augustyns, Van Der Veken, De Meester, Lamkanfi: "DPP8/DPP9 inhibition elicits canonical Nlrp1b inflammasome hallmarks in murine macrophages." dans: Life science alliance, Vol. 2, Issue 1, (2020) (PubMed).

Hamarsheh, Osswald, Saller, Unger, De Feo, Vinnakota, Konantz, Uhl, Becker, Lübbert, Shoumariyeh, Schürch, Andrieux, Venhoff, Schmitt-Graeff, Duquesne, Pfeifer, Cooper, Lengerke, Boerries, Duyster et al.: "Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation. ..." dans: Nature communications, Vol. 11, Issue 1, pp. 1659, (2020) (PubMed).

Wooff, Fernando, Wong, Dietrich, Aggio-Bruce, Chu-Tan, Robertson, Doyle, Man, Natoli: "Caspase-1-dependent inflammasomes mediate photoreceptor cell death in photo-oxidative damage-induced retinal degeneration." dans: Scientific reports, Vol. 10, Issue 1, pp. 2263, (2020) (PubMed).

Cai, Ge, Mennone, Hoque, Ouyang, Boyer: "Inflammasome Is Activated in the Liver of Cholestatic Patients and Aggravates Hepatic Injury in Bile Duct-Ligated Mouse." dans: Cellular and molecular gastroenterology and hepatology, Vol. 9, Issue 4, pp. 679-688, (2020) (PubMed).

Deng, Guo, Tam, Johnson, Brickey, New, Lenox, Shi, Golenbock, Koller, McKinnon, Beutler, Ting: "Platelet-activating factor (PAF) mediates NLRP3-NEK7 inflammasome induction independently of PAFR." dans: The Journal of experimental medicine, Vol. 216, Issue 12, pp. 2838-2853, (2020) (PubMed).

Sharif, Wang, Wang, Magupalli, Andreeva, Qiao, Hauenstein, Wu, Núñez, Mao, Wu: "Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome." dans: Nature, Vol. 570, Issue 7761, pp. 338-343, (2020) (PubMed).

Xue, Xi, Liu, Guo, Zhang, Zhang, Li, Yang, Zhou, Yang, Zhang, Zhang, Gu, Yang, Da, Yao, Duo, Zhang: "miR-21 promotes NLRP3 inflammasome activation to mediate pyroptosis and endotoxic shock." dans: Cell death & disease, Vol. 10, Issue 6, pp. 461, (2020) (PubMed).

Sanchez-Lopez, Zhong, Stubelius, Sweeney, Booshehri, Antonucci, Liu-Bryan, Lodi, Terkeltaub, Lacal, Murphy, Hoffman, Tiziani, Guma, Karin: "Choline Uptake and Metabolism Modulate Macrophage IL-1β and IL-18 Production." dans: Cell metabolism, Vol. 29, Issue 6, pp. 1350-1362.e7, (2020) (PubMed).

Mamantopoulos, Frising, Asaoka, van Loo, Lamkanfi, Wullaert: "El Tor Biotype Vibrio cholerae Activates the Caspase-11-Independent Canonical Nlrp3 and Pyrin Inflammasomes." dans: Frontiers in immunology, Vol. 10, pp. 2463, (2019) (PubMed).

Détails sur Caspase 1 p20

Antigène: Caspase 1 p20

Autre désignation: Caspase-1 p20 (Caspase 1 p20 Produits)

Sujet: Caspase-1 is the best-described inflammatory caspase. It processes the cytokines interleukin-1beta (IL-1beta) and IL-18 and induces pyroptotic cell death. Caspase-1 is activated by multiprotein complexes called Inflammasomes in response to numerous stimuli that are detected through distinct inflammasomes. NLRC4 responds to cytosolic flagellin, murine NLRP1b responds to anthrax lethal toxin, AIM2 responds to cytosolic DNA and NLRP3 responds to a variety of agonists including crystals.

UniProt: P29452