HLA-ABC anticorps

N° du produit ABIN1177256

Détail du produit anti-HLA-ABC anticorps

Antigène: HLA-ABC

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp HLA-ABC est non-conjugé

Application: Flow Cytometry (FACS), Blocking Reagent (BR)

Marque: BD Pharmingen™

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.

Immunogène: Polyclonal Human NK Cell Line

Clone: DX17

Isotype: IgG1 kappa

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.

Agent conservateur: Azide free

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Références pour anticorps anti-HLA-ABC (ABIN1177256)

Gumperz, Litwin, Phillips, Lanier, Parham: "The Bw4 public epitope of HLA-B molecules confers reactivity with natural killer cell clones that express NKB1, a putative HLA receptor." dans: The Journal of experimental medicine, Vol. 181, Issue 3, pp. 1133-44, (1995) (PubMed).

Lanier, Gumperz, Parham, Melero, López-Botet, Phillips: "The NKB1 and HP-3E4 NK cells receptors are structurally distinct glycoproteins and independently recognize polymorphic HLA-B and HLA-C molecules." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 154, Issue 7, pp. 3320-7, (1995) (PubMed).

Morton, Kirsch, Nance, Evans, Korman, Strominger: "Orientation of loci within the human major histocompatibility complex by chromosomal in situ hybridization." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 81, Issue 9, pp. 2816-20, (1984) (PubMed).

Bach, Amos: "Hu-1: Major histocompatibility locus in man." dans: Science (New York, N.Y.), Vol. 156, Issue 3781, pp. 1506-8 (PubMed).

Détails sur HLA-ABC

Antigène: HLA-ABC

Autre désignation: HLA-A/B/C (HLA-ABC Produits)

Synonymes: anticorps HLAA, anticorps major histocompatibility complex, class I, A, anticorps HLA-A

Sujet: The DX17 monoclonal antibody reacts with a monomorphic epitope expressed on all HLA (human leukocyte antigen) class I molecules examined. DX17 immunoprecipitates HLA class I heavy chains (45 kDa) and beta2-microglobulin (12kDa) from radiolabeled human cell lines. HLA is determined by a complex segment of the short arm of chromosome 6 and there are many human HLAs encoded in this segment. The antigenic agglomerate is called MHC, for major histocompatibility complex. Examples of class I loci are HLA-A, -B, and -C, which are serologically assayed, class II loci, e.g., HLA-D/DR and DC1, are tested by lymphocytotoxic methods.

Pathways: TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints