ITGA1
Reactivité: Humain
IHC, ELISA, IF
Hôte: Lapin
Polyclonal
unconjugated
Restrictions
For Research Use only
Format
Liquid
Concentration
1.0 mg/mL
Buffer
No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.
Agent conservateur
Azide free
Stock
4 °C
Stockage commentaire
Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
Mendrick, Kelly, duMont, Sandstrom: "Glomerular epithelial and mesangial cells differentially modulate the binding specificities of VLA-1 and VLA-2." dans: Laboratory investigation; a journal of technical methods and pathology, Vol. 72, Issue 3, pp. 367-75, (1995) (PubMed).
Miyake, Sakurai, Okumura, Yagita: "Identification of collagen and laminin receptor integrins on murine T lymphocytes." dans: European journal of immunology, Vol. 24, Issue 9, pp. 2000-5, (1994) (PubMed).
Hemler: "VLA proteins in the integrin family: structures, functions, and their role on leukocytes." dans: Annual review of immunology, Vol. 8, pp. 365-400, (1990) (PubMed).
The Ha31/8 antibody reacts with the 180-kDa integrin alpha1 chain (CD49a), which is a transmembrane glycoprotein that non-covalently associates with the integrin beta1 subunit (CD29) to form the alpha1beta1 (complex known as VLA-1). VLA-1 has been reported to be expressed on activated T cells, monocytes, smooth muscle cells, and endothelial cells. It is a receptor for collagen and laminin. The Ha31/8 monoclonal antibody is specific for both rat and mouse CD49a. It has been reported that Ha31/8 antibody can block VLA-1-mediated binding of rat cells to collagen. Synonyms: Integrin alpha1 chain