CD72 anticorps
-
- Antigène Voir toutes CD72 Anticorps
- CD72 (CD72 Molecule (CD72))
-
Reactivité
- Humain
-
Hôte
- Souris
-
Clonalité
- Monoclonal
-
Conjugué
- Cet anticorp CD72 est non-conjugé
-
Application
- Flow Cytometry (FACS), Immunoprecipitation (IP)
- Specificité
- The antibody reacts with CD72, a 39-43 kDa type II membrane glycoprotein (C-type lectin family).
- Purification
- Precipitation methods and ion exchange chromatography
- Pureté
- > 95 % (by SDS-PAGE)
- Immunogène
- Normal human lymphocytes from a lymph node
- Clone
- 3F3
- Isotype
- IgG2b
- Top Product
- Discover our top product CD72 Anticorps primaire
-
-
- Indications d'application
-
Immunoprecipitation. Flow Cytometry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
-
- Concentration
- 1.0 mg/mL
- Buffer
- Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing. Dilute only prior to immediate use
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store the antibody (undiluted) at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
-
- Antigène
- CD72 (CD72 Molecule (CD72))
- Autre désignation
- CD72 (CD72 Produits)
- Synonymes
- anticorps CD72c, anticorps Ly-19, anticorps Ly-32, anticorps Ly-m19, anticorps Lyb-2, anticorps CD72b, anticorps LYB2, anticorps CD72 antigen, anticorps CD72 molecule, anticorps Cd72, anticorps CD72
- Sujet
- CD72 is a transmembrane glycoprotein expressed as a homodimer especially in B cells, but also in other antigen presenting cells such as dendritic cells and macrophages. Through one of its immunoreceptor tyrosine-based inhibitory motives (ITIMs), CD72 interacts with tyrosine phosphatase SHP-1, thereby suppressing B cell responsiveness. Binding of CD72 with its ligand CD100 (Sema4D) prevents BCR association and phosphorylation of CD72 and results in dissociation of SHP-1 from CD72, thus enables B cell activation. CD72 is a pan-B cell marker expressed throughout the B lymphocytes diferentiation with the exception of plasma cells, it is also present on follicular dendritic cells.Synonyms: B-Cell marker, B-cell differentiation antigen CD72, Ly-32, Ly32, Lyb-2, Lymphocyte antigen 32
- ID gène
- 971
- NCBI Accession
- NP_001773
- UniProt
- P21854
- Pathways
- BCR Signaling
-