Huntingtin anticorps (AA 1844-2131)
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- Antigène Voir toutes Huntingtin (HTT) Anticorps
- Huntingtin (HTT)
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Épitope
- AA 1844-2131
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Reactivité
- Humain, Souris, Lapin
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp Huntingtin est non-conjugé
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Application
- Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Specificité
- This antibody reacts with an epitope corresponding to the HDB region (amino acids 1844-2131) of the Huntingtin protein. The combined use of Clone HDB4E10 (Cat.-No SM1661), HDC8A4 (Cat.-No SM1662) and HDA3E10 (Cat.-No SM1660) demonstrate that huntingtin is enriched in neuronal cells in the brain.
- Purification
- Purified
- Immunogène
- Recombinant protein corresponding to amino acids 1844 - 2131 of huntingtin
- Clone
- HDB4E10
- Isotype
- IgG1
- Top Product
- Discover our top product HTT Anticorps primaire
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- Indications d'application
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Western Blot: Clone HDB4E10 detects a 350KD band on western blots but also detects smaller degradation products of huntingtin. Immunoprecipitation. Immunohistochemistry on frozen sections. Recommended positive control tissue: Brain.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- PBS, 0.09 % Sodium Azide
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Antigène
- Huntingtin (HTT)
- Autre désignation
- Huntingtin (HTT Produits)
- Synonymes
- anticorps HTT, anticorps hd, anticorps ZHD, anticorps CG9995, anticorps Dmel\\CG9995, anticorps HD, anticorps Hsap\\HD, anticorps Htt, anticorps dHtt, anticorps dhtt, anticorps SLC6A4, anticorps huntington, anticorps it15, anticorps htt, anticorps IT15, anticorps AI256365, anticorps C430023I11Rik, anticorps Hd, anticorps Hdh, anticorps huntingtin, anticorps HTT, anticorps htt, anticorps LOC373520, anticorps Htt
- Sujet
- Huntington's disease (HD) is a neurodegenerative disorder caused by an expanding polyglutamine repeat in the huntingtin gene. HD is a mid-life onset autosomal dominant neurodegeneative disease that is characterized by psychiatric disorders, dementia, and involuntary movements (chorea), leading to death in 10-20 years. The HD gene product is widely expressed in human tissues, with the highest level of expression in the brain. The huntingtin gene product is expressed at similar levels in patients and controls, which suggests that the expansion of the polyglutamine repeat induces a toxic gain of function perhaps through interactions with other cellular proteins. Using yeast two-hybrid system, HAP1 (huntingtin associated protein 1) has been identified, that associates with huntingtin protein. The In vitro data suggest that the association between HAP1 and huntingtin is enhanced by increasing length of glutamine repeat.Synonyms: HD, HTT, Huntington Disease Protein, IT15
- ID gène
- 3064
- NCBI Accession
- NP_002102
- UniProt
- P42858
- Pathways
- Signalisation PI3K-Akt, Hormone Transport, Transition Metal Ion Homeostasis, Tube Formation, Protein targeting to Nucleus, Dicarboxylic Acid Transport
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