LAT2 anticorps (Cytoplasmic Domain)

N° du produit ABIN125754

Détail du produit anti-LAT2 anticorps

Antigène: LAT2 (Linker For Activation of T Cells Family, Member 2 (LAT2))

Épitope: AA 124-203, Cytoplasmic Domain

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LAT2 est non-conjugé

Application: Western Blotting (WB)

Specificité: The polyclonal antibody recognizes N-terminal cytoplasmic domain of mouse Non-T cell Activation Linker (NTAL), also known as LAB (linker of activated B cells), a 25 kDa transmembrane adaptor protein present in membrane microdomains (rafts) of B cells, NK cells and myeloid cells.

Aucune reactivité croisée: Humain

Réactivité croisée (Details): Mouse, Other species Not tested

Purification: Purified by ligand affinity chromatography.

Pureté: > 95 % (by SDS-PAGE)

Immunogène: Recombinant N-terminal cytoplasmic domain (aa 124-203) of mouse NTAL.

Information d'application

Indications d'application: Western blotting: Recommended dilution: 1 μg/mL, positive control: murine spleen, non-reducing conditions.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Do not freeze.

Références pour anticorps anti-LAT2 (ABIN125754)

Volná, Lebduska, Dráberová, Símová, Heneberg, Boubelík, Bugajev, Malissen, Wilson, Horejsí, Malissen, Dráber: "Negative regulation of mast cell signaling and function by the adaptor LAB/NTAL." dans: The Journal of experimental medicine, Vol. 200, Issue 8, pp. 1001-13, (2004) (PubMed).

Détails sur LAT2

Antigène: LAT2 (Linker For Activation of T Cells Family, Member 2 (LAT2))

Autre désignation: NTAL / LAB (LAT2 Produits)

Synonymes: anticorps LAB, anticorps NTAL, anticorps WBSCR15, anticorps WBSCR5, anticorps WSCR5, anticorps LAT2, anticorps MGC139435, anticorps Ntal, anticorps Wbscr5, anticorps AW125574, anticorps Wbscr15, anticorps linker for activation of T-cells family member 2, anticorps linker for activation of T cells family, member 2, anticorps LAT2, anticorps Lat2

Sujet: Linker for activation of T cells family member 2,NTAL (non-T cell activation linker), also known as LAB (linker for activation of B cells), is a 30 kDa double-palmitoylated transmembrane adaptor protein expressed by B cells, NK cells, mast cells and macrophages. It is a negative regulator of early stages of BCR-dependent B cell signaling and serves as a negative regulator also in mast cells. However, in mast cells, NTAL also contributes to some activation processes, partially overlapping with LAT function.,LAB, LAT2

ID gène: 7462

UniProt: Q9GZY6

Pathways: Fc-epsilon Receptor Signaling Pathway, BCR Signaling