LRP1 anticorps
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- Antigène Voir toutes LRP1 Anticorps
- LRP1 (Low Density Lipoprotein Receptor-Related Protein 1 (LRP1))
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Reactivité
- Humain, Souris, Rat, Lapin, Hamster
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp LRP1 est non-conjugé
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Application
- Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Specificité
- 8B8 specifically reacts with the 85 kDa β-chain of human LRP/α2MR which is expressed in a restricted spectrum of cell types (for a recent review cf. Herz & Strickland). A strong immunohistochemical reaction is seen in hepato-cytes, tissue macrophages, subsets of neurones and as-trocytes in the central nervous system, fibroblasts, smooth muscle cells, and monocyte-derived foam cells in athero-sclerotic lesions in the arterial wall. The antibody can also be used for the characterization of a subset of myelo-monocytic subtypes of chronic and acute leukemia (CD 91).
- Purification
- Affinity Chromatography on Protein A.
- Immunogène
- Human LRP/alpha2MR
- Clone
- 8B8
- Isotype
- IgG1
- Top Product
- Discover our top product LRP1 Anticorps primaire
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- Indications d'application
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Immunofluorescence. Immunohistochemistry: 1/20. Flow Cytometry. Immunoblotting.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Reconstitution
- Restore in 1 mL dist. water.
- Buffer
- Final Solution contains PBS buffer, pH 7.4 containing 0.5 % BSA without preservatives.
- Agent conservateur
- Without preservative
- Conseil sur la manipulation
- This product is photosensitive and should be protected from light
- Stock
- 4 °C
- Stockage commentaire
- Prior to and following reconstitution store the antibody undiluted at 2-8 °C. DO NOT FREEZE!
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- Antigène
- LRP1 (Low Density Lipoprotein Receptor-Related Protein 1 (LRP1))
- Autre désignation
- CD91 / LRP1 (LRP1 Produits)
- Synonymes
- anticorps A2MR, anticorps APOER, anticorps APR, anticorps CD91, anticorps IGFBP3R, anticorps LRP, anticorps LRP1A, anticorps TGFBR5, anticorps A2mr, anticorps AI316852, anticorps Lrp, anticorps LRP-1, anticorps LDL receptor related protein 1, anticorps prolow-density lipoprotein receptor-related protein 1, anticorps low density lipoprotein receptor-related protein 1, anticorps LRP1, anticorps Lrp1, anticorps LOC100414789
- Sujet
- Low density lipoprotein receptor-related protein (also known as low density LRP, LRP1, alpha-2-macroglobulin receptor or Apolipoprotein E receptor) is an endocytotic receptor that is involved both in endocytosis and in phagocytosis of apoptotic cells. It is required for early embryonic development, is involved in cellular lipid homeostasis, and may play a role in APP metabolism, kinase-dependent intracellular signalling, neuronal calcium signalling and neurotransmission. Low density LRP also plays a role in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha-2-macroglobulin), and is involved in the local metabolism of complexes of plasminogen activators and their endogenous ligands. Low density LPR is postulated to be one of the major players in host resistance to HIV. The precursor low density LRP molecule is cleaved post-translationally to form a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515), which remains non-covalently associated with LRP-85. Following cleavage, the intracellular domain (LPRICD) is present in both the cytoplasm and the nucleus.Synonyms: A2MR, APOER, APR, Alpha-2-macroglobulin receptor, Apolipoprotein E receptor, Prolow-density lipoprotein receptor-related protein 1
- ID gène
- 4035
- NCBI Accession
- NP_002323
- UniProt
- Q07954
- Pathways
- Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling
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