PMS2 anticorps
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- Antigène Voir toutes PMS2 Anticorps
- PMS2 (PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2))
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp PMS2 est non-conjugé
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Application
- Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Specificité
- The antibody recognizes ~100 kDa PMS2.
- Purification
- Peptide Affinity Chromatography.
- Immunogène
- Synthetic peptide surrounding amino acid 846 of human PMS2
- Top Product
- Discover our top product PMS2 Anticorps primaire
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- Indications d'application
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Western Blot: 0.5-4 μg/mL. Immunoprecipitation: 10-20 μg/mL. Immunohistochemistry: 10-20 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- PBS containing 30 % Glycerol, 0.5 % BSA, and 0.01 % Thimerosal.
- Agent conservateur
- Thimerosal (Merthiolate)
- Précaution d'utilisation
- This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- -20 °C/-80 °C
- Stockage commentaire
- Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -70 °C.
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- Antigène
- PMS2 (PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2))
- Autre désignation
- PMS2 (PMS2 Produits)
- Synonymes
- anticorps HNPCC4, anticorps PMS2CL, anticorps PMSL2, anticorps AW555130, anticorps Pmsl2, anticorps PMS1 homolog 2, mismatch repair system component, anticorps PMS1 homolog2, mismatch repair system component, anticorps mismatch repair endonuclease PMS2, anticorps PMS2, anticorps Pms2, anticorps LOC463257, anticorps LOC107984056
- Sujet
- Inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were initially demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 - 45 % of pancreatic, gastric, breast, ovarian and small cell lung cancers also display microsatellite instability has been interpreted to suggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression. Two additional homologs of the prokaryotic MutL gene, designated PMS1 and PMS2, have been identified and shown to be mutated in the germline of HNPCC patients.Synonyms: DNA mismatch repair protein PMS2, Mismatch repair endonuclease PMS2, PMS1 protein homolog 2, PMSL2
- ID gène
- 5395
- NCBI Accession
- NP_000526
- UniProt
- P54278
- Pathways
- Réparation de l'ADN, Production of Molecular Mediator of Immune Response
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